Research Article

Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure

Figure 1

Interactions among GSTM1 genotype, gender, and prenatal TSE with regard to asthma development at 6 years of age. Prenatal TSE significantly increased the risk of childhood asthma in females with the GSTM1 null genotype (, OR: 4.107, 95% CI: 1.669–10.107), but not in the other 3 groups. Furthermore, among children without prenatal TSE, females with the GSTM1 null genotype had a significantly lower risk of developing childhood asthma (, OR: 0.436, 95% CI: 0.197–0.966).
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