Hypofractionation in Prostate Cancer: Radiobiological Basis and Clinical Appliance

Figure 1

(Based on data from Withers and Thames [5, 6]) the steepness and curvature of these lines are determined by the 𝛼/𝛽 ratio. The graph indicates a greater sensitivity of late responses to changes in dose per fraction: using lower doses per fraction tends to spare late reactions.