Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer

Table 1

Correlation between NED and clinicopathological parameters.

Property	NED		𝑃 value
	Negative	Positive; total (SG1, SG2, and SG3)
Age
<65	59	38 (14, 5, 19)	0.532
≥65	41	33 (15, 6, 12)
Gender
Male	65	33 (10, 6, 17)	0.019
Female	35	38 (19, 5, 14)
Tumor location
Colon	70	45 (14, 8, 23)	0.410
Rectum	30	26 (15, 3, 8)
Lymphatic invasion
Yes	24	19 (9, 1, 9)	0.722
No	76	52 (20, 10, 22)
Lymph nodes discovered
≥12	70	53 (22, 8, 23)	0.605
<12	30	18 (7, 3, 8)
TNM stage
I	5	3 (1, 1, 1)	0.135
II	28	14 (5, 3, 6)
III	47	46 (18, 6, 21)
IV	20	8 (5, 1, 3)
Chemotherapy
Yes	54	28 (11, 4, 13)	0.065
No	46	43 (18, 7, 18)

SG: subgroup; SG 1: 1–10 positive cells/HPF; SG 2: 11–20 cells/HPF; SG 3: >20 cells/HPF; NED: neuroendocrine differentiation; TNM: tumor, node, metastasis.