Alzheimer’s Disease and HLA-A2: Linking Neurodegenerative to Immune Processes through an In Silico Approach

Table 1

Description of the included articles.

Study	Country/population	Cases/controls	Typing/technique	Diagnostic criteria	Reference
Henschke et al., 1978	Canada	34/239	Lymphotoxicity	Exclusion of other causes of dementia	[21]
Sulkava et al., 1980	Finland	32/35	Lymphotoxicity	Exclusion of other causes of dementia	[22]
Wilcox et al., 1980	United Kingdom	18/342	Lymphotoxicity	Exclusion of other causes of dementia	[23]
Whalley et al., 1980	United Kingdom	14/64	Lymphotoxicity	Exclusion of other causes of dementia	[24]
Majsky and Vojtechovsky, 1983	Czechoslovakia	38/301	Lymphotoxicity	Exclusion of other causes of dementia-Haschinsky	[25]
Reed et al., 1983	United States	44/100	Lymphotoxicity	Exclusion of other causes of dementia	[26]
Reisner et al., 1983	United States	52/305	Amos modified method	Histopathological confirmation	[27]
Renvoize, 1984	United Kingdom	124/458	Lympho-toxicity	Exclusion of other causes of dementia	[28]
Endo et al., 1986	Japan	122/66	Lympho-toxicity	DSM III	[36]
Small and Matsuyama, 1986	United States	36/25	Lympho-toxicity	DSM III	[29]
Payami et al., 1991	United States	54/263	Lymphotoxicity	NINCDS-ADRDA	[30]
Middleton et al., 1999	United Kingdom	95/45	PCR SSOP	Histopathological confirmation	[31]
Small et al., 1999	United States	479/233	PCR SSP	NINCDS-ADRDA	[32]
Harris et al., 2000	United Kingdom	178/161	PCR SSP	NINCDS-ADRDA	[12]
Lehmann et al., 2001	United Kingdom	55/73	PCR SSP	Histopathological confirmation CERAD	[11]
Araria-Goumidi et al., 2002	France	451/477	Duplex-PCR	DSM III and NINCDS-ADRDA	[33]
Listì et al., 2006	Italy	460/266	PCR SSP	NINCDS-ADRDA	[34]
Ma et al., 2008	China	160/167	SBT	NINCDS-ADRDA	[13]
Guerini et al., 2009	Italy	173/258	PCR SSP	NINCDS-ADRDA	[35]

AD: Alzheimer’s disease, PCR SSOP: Polymerase chain reaction and sequence specific oligonucleotide probe, PCR SSP: Polymerase chain reaction and sequence specific primers, SBT: Sequence based typing, DSM: Diagnostic and Statistical Manual, NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association, CERAD: Consortium to Establish a Registry for Alzheimer’s Disease.