Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population
Table 2
Endothelial nitric oxide synthase (eNOS) gene polymorphisms and the risk of hypertension in the study population.
eNOS gene polymorphisms
Control ()
Case ()
Crude OR (95% CI)
value
Adjusted OR#(95% CI)
value
eNOS gene intron 4 ab polymorphism
bb
256 (73.2%)
190 (54.3%)
1.000
—
1.000
—
ab
89 (25.4%)
142 (40.6%)
2.15 (1.55–2.97)
0.002*
2.23 (1.55–3.20)
0.000*
aa
5 (1.4%)
18 (5.1%)
4.85 (1.77–13.30)
0.000*
6.81 (2.29–20.25)
0.001*
b
601 (85.9%)
522 (74.6%)
1.000
—
—
—
a
99 (14.1%)
178 (25.4%)
2.07 (1.56–2.74)
0.000*
—
—
(aa + ab)/bb
2.29 (1.67–3.15)
0.000*
2.33 (1.65–3.30)
0.000*
aa/(ab + bb)
3.74 (1.37–10.19)
0.010*
3.85 (1.34–11.03)
0.012*
Homozygous for rare allele versus homozygous for common allele
4.85 (1.77–13.30)
0.002*
6.81 (2.29–20.25)
0.001*
Heterozygous for the common allele versus homozygous for the common allele
2.15 (1.55–2.97)
0.000*
2.21 (1.55–3.15)
0.000*
eNOS gene exon 7 Glu298Asp polymorphism
GG
296 (84.6%)
194 (55.4%)
1.000
—
1.000
—
GT
50 (14.3%)
133 (38.0%)
4.06 (2.80–5.89)
0.000*
3.98 (2.65–5.98)
0.000*
TT
4 (1.1%)
23 (6.6%)
8.77 (2.99–25.76)
0.000*
7.84 (2.57–23.96)
0.000*
G
642 (91.7%)
521 (74.4%)
1.000
—
—
—
T
58 (8.3%)
179 (25.6%)
3.80 (2.74–5.29)
0.000*
—
—
(TT + GT)/GG
4.41 (3.08–6.31)
0.000*
4.25 (2.90–6.22)
0.000*
TT/(GT + GG)
6.08 (2.08–17.78)
0.001*
6.35 (2.10–19.22)
0.001*
Homozygous for rare allele versus homozygous for common allele
8.77 (2.99–25.76)
0.000*
7.84 (2.57–23.96)
0.000*
Heterozygous for the common allele versus homozygous for the common allele
4.06 (2.80–5.89)
0.000*
3.88 (2.60–5.78)
0.000*
eNOS gene T786C polymorphism
TT
214 (61.1%)
200 (57.1%)
1.000
—
1.000
—
TC
127 (36.3%)
139 (39.8%)
1.17 (0.86–1.59)
0.315
1.19 (0.85–1.66)
0.324
CC
9 (2.6%)
11 (3.1%)
1.31 (0.53–3.22)
0.560
1.41 (0.52–3.81)
0.497
T
555 (79.3%)
539 (77.0%)
1.000
—
—
—
C
145 (20.7%)
161 (23.0%)
1.14 (0.88–1.49)
0.301
—
—
(CC + TC)/TT
1.18 (0.87–1.60)
0.282
1.21 (0.87–1.67)
0.255
CC + (TC + TT)
1.23 (0.50–3.01)
0.651
1.25 (0.48–3.24)
0.647
Homozygous for rare allele versus homozygous for common allele
1.31 (0.53–3.22)
0.560
1.41 (0.52–3.81)
0.497
Heterozygous for the common allele versus homozygous for the common allele
1.17 (0.86–1.59)
0.315
1.19 (0.85–1.66)
0.324
OR: odds ratio. CI: confidence interval.
#Adjusted for age, sex, extra salt intake, smoking, tobacco chewing and habit of alcohol consumption, and eNOS gene polymorphisms.
*Statistically significant ( value ≤ 0.05).
