Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population

Table 5

Stratified analysis to study the relation between endothelial nitric oxide synthase (eNOS) gene polymorphisms and the risk of hypertension in the subgroups with selected habits in the study population.

eNOS gene polymorphism	Parameter		Odds ratio; (95% CI)	value
eNOS gene intron 4 ab polymorphism	Tobacco use (either smoking/chewing or both)	Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 aa genotype	14.00; (1.20–163.37)	0.035*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 ab genotype	8.06; (4.41–14.73)	0.000*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 bb genotype	4.09; (2.73–6.12)	0.000*
	Alcohol consumption	Subjects who have the habit of alcohol consumption with eNOS4 aa genotype	12.00; (1.20–143.73)	0.035*
		Subjects who have the habit of alcohol consumption with eNOS4 ab genotype	1.56; (0.91–2.65)	0.105
		Subjects who have the habit of alcohol consumption with eNOS4 bb genotype	2.07; (1.41–3.04)	0.000*
eNOS gene exon 7 Glu298Asp polymorphism	Tobacco use (either smoking/chewing or both)	Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 GG genotype	5.56; (3.72–8.31)	0.000*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 GT genotype	3.86; (1.95–7.67)	0.000*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 TT genotype	2.29; (0.27–19.66)	0.451
	Alcohol consumption	Subjects who have the habit of alcohol consumption with eNOS7 GG genotype	1.95; (1.35–2.81)	0.000*
		Subjects who have the habit of alcohol consumption with eNOS7 GT genotype	2.41; (1.24–4.69)	0.009*
		Subjects who have the habit of alcohol consumption with eNOS7 TT genotype	1.09; (0.13–9.12)	0.936
eNOS gene T786C polymorphism	Tobacco use (either smoking/chewing or both)	Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C TT genotype	5.84; (3.79–8.98)	0.000*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C TC genotype	4.51; (2.69–7.56)	0.000*
		Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C CC genotype	9.00; (1.14–71.04)	0.037*
	Alcohol consumption	Subjects who have the habit of alcohol consumption eNOS T786C TT genotype	2.07; (0.47–3.06)	0.547
		Subjects who have the habit of alcohol consumption with eNOS T786C TC genotype	1.75; (0.18–2.86)	0.084
		Subjects who have the habit of alcohol consumption with eNOS T786C CC genotype	2.92; (0.41–20.90)	0.287

*Statistically significant ( value ≤ 0.05).
CI: confidence interval.