Research Article

In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats

Figure 3

Plasma concentration-time curve after i.v. administration of TW01003 (6.7 mg/kg) to a rat. Plasma samples were collected and subjected to enzymatic treatment by sulfatase or glucuronidase. This method was used for the identification of TW01003 sulfate or glucuronide conjugate after TW01003 dosing.
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