Novel Lipid-Free Nanoformulation for Improving Oral Bioavailability of Coenzyme Q10

Table 1

Physicochemical properties of nano-CoQ10s modified with various surfactants and the stability of nano-CoQ10s during 180 days of storage in sealed brown bottles at 25°C (𝑛=3).

	1 day			180 days
	Particle size (nm)	Polydispersity index	Zeta potential (mV)	Particle size (nm)	Polydispersity index	Zeta potential (mV)
Nano-CoQ10-TPGS	66.3 ± 1.5	0.197 ± 0.012	−19.6 ± 1.5	72.0 ± 2.0	0.201 ± 0.01	−20.1 ± 1.0
Nano-CoQ10-PHCO	77.3 ± 2.1	0.109 ± 0.044	−12.8 ± 1.4	77.7 ± 1.2	0.117 ± 0.027	−13.5 ± 0.7
Nano-CoQ10-PSAE	89.0 ± 3.0	0.175 ± 0.014	−39.1 ± 1.1	92.0 ± 1.0	0.182 ± 0.007	−39.5 ± 0.6
Nano-CoQ10-SP	92.7 ± 1.5	0.339 ± 0.072	−37.4 ± 1.0	109.3 ± 2.1	0.297 ± 0.012	−37.5 ± 0.9
Nano-CoQ10-SL	88.0 ± 1.0	0.527 ± 0.033	−41.6 ± 1.4	102.7 ± 1.5	0.453 ± 0.063	−42.2 ± 0.8