Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 802189, 9 pages
http://dx.doi.org/10.1155/2014/802189
Research Article

Effect of the Zataria multiflora on Systemic Inflammation of Experimental Animals Model of COPD

1Neurogenic Inflammation Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
2Pharmaceutical Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

Received 17 February 2014; Revised 8 May 2014; Accepted 9 May 2014; Published 11 June 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Mohammad Hossein Boskabady and Lilla Gholami Mhtaj. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, “Chronic Obstructive Pulmonary Disease (COPD),” Fact Sheet 315, 2011. View at Google Scholar
  2. W. MacNee, “Pathogenesis of chronic obstructive pulmonary disease,” Proceedings of the American Thoracic Society, vol. 2, no. 4, pp. 258–266, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. T. L. Hackett, D. A. Knight, and D. D. Sin, “Potential role of stem cells in management of COPD,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 5, no. 1, pp. 81–88, 2010. View at Google Scholar · View at Scopus
  4. I. K. Demedts, T. Demoor, K. R. Bracke, G. F. Joos, and G. G. Brusselle, “Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema,” Respiratory Research, vol. 7, article 53, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. P. J. Barnes, “New concepts in chronic obstructive pulmonary disease,” Annual Review of Medicine, vol. 54, no. 1, pp. 113–129, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. P. J. Barnes, “Chronic obstructive pulmonary disease • 12: new treatments for COPD,” Thorax, vol. 58, no. 9, pp. 803–808, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. T. C. O'Shaughnessy, T. W. Ansari, N. C. Barnes, and P. K. Jeffery, “Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1,” The American Journal of Respiratory and Critical Care Medicine, vol. 155, no. 3, pp. 852–857, 1997. View at Google Scholar · View at Scopus
  8. M. Saetta, S. Baraldo, L. Corbino et al., “CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease,” The American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 2, pp. 711–717, 1999. View at Google Scholar · View at Scopus
  9. Y. Qiu, J. Zhu, V. Bandi et al., “Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease,” The American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 8, pp. 968–975, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Saetta, S. Baraldo, and R. Zuin, “Neutrophil chemokines in severe exacerbations of chronic obstructive pulmonary disease: fatal chemo-attraction?” The American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 8, pp. 911–913, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. W. MacNee, “Oxidants/antioxidants and COPD,” Chest, vol. 117, no. 5, supplement 1, pp. 303S–317S, 2000. View at Google Scholar · View at Scopus
  12. SCOP, Thymi herba, Monographs on the Medicinal Uses of Plant Drugs, European Scientific Cooperative on Phytotherapy, Exeter, UK, 1997.
  13. M. S. Ali, M. Saleem, Z. Ali, and V. U. Ahmad, “Chemistry of Zataria multiflora (Lamiaceae),” Phytochemistry, vol. 55, no. 8, pp. 933–936, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shafiee and K. Javidnia, “Composition of essential oil of Zataria multiflora,” Planta Medica, vol. 63, no. 4, pp. 371–372, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. O. Saǧdiç, “Sensitivity of four pathogenic bacteria to Turkish thyme and oregano hydrosols,” Food Science and Technology, vol. 36, no. 5, pp. 467–473, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Misaghi and A. A. Basti, “Effects of Zataria multiflora Boiss. essential oil and nisin on Bacillus cereus ATCC 11778,” Food Control, vol. 18, no. 9, pp. 1043–1049, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. A. Basti, A. Misaghi, and D. Khaschabi, “Growth response and modelling of the effects of Zataria multiflora Boiss. essential oil, pH and temperature on Salmonella typhimurium and Staphylococcus aureus,” Food Science and Technology, vol. 40, no. 6, pp. 973–981, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. S. S. Dehkordi, S. M. R. Rohani, H. Tajik, M. Moradi, and J. Aliakbarlou, “Antimicrobial effects of lysozyme in combination with Zataria multiflora Boiss. essential oil at different pH and NaCl concentrations on E. coli O157:H7 and Staphylococcus aureus,” Journal of Animal and Veterinary Advances, vol. 7, no. 11, pp. 1458–1463, 2008. View at Google Scholar · View at Scopus
  19. A. Z. Mahmoudabadi, M. A. Dabbagh, and Z. Fouladi, “In vitro anti-Candida activity of Zataria multiflora Boiss.,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 3, pp. 351–353, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Ramezani, H. Hosseinzadeh, and S. Samizadeh, “Antinociceptive effects of Zataria multiflora Boiss. fractions in mice,” Journal of Ethnopharmacology, vol. 91, no. 1, pp. 167–170, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Babaie, N. Yasa, A. Mohammadirad, R. Khorasani, and M. Abdollahi, “On the anti oxidative stress potential of Zataria multiflora Boiss. (Avishan shirazi) in rats,” International Journal of Pharmacology, vol. 3, no. 6, pp. 510–514, 2007. View at Google Scholar · View at Scopus
  22. Avicenna, The Canon of Medicine, edited by A. R. Sharaf-Kandi, book 2, Soroush Press, Tehran, Iran, 1st edition, 1985 (Persian).
  23. H. Shokri, F. Asadi, A. R. Bahonar, and A. R. Khosravi, “The role of Zataria multiflora essence (Iranian herb) on innate immunity of animal model,” Iranian Journal of Immunology, vol. 3, no. 4, pp. 164–168, 2006. View at Google Scholar · View at Scopus
  24. A. Ghannadi, S. E. Sajjadi, D. Abedi, J. Yousefi, and R. Daraei-Ardekani, “The in vitro activity of seven Iranian plants of the Lamiaceae family against Helicobacter pylori,” Nigerian Journal of Natural Products and Medicine, vol. 8, pp. 40–42, 2004. View at Google Scholar
  25. L. A. Nakhai, A. Mohammadirad, N. Yasa et al., “Benefits of Zataria multiflora Boiss. in experimental model of mouse inflammatory bowel disease,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 43–50, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Hosseinzadeh, M. Ramezani, and G.-A. Salmani, “Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss. extracts in mice and rats,” Journal of Ethnopharmacology, vol. 73, no. 3, pp. 379–385, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Meister, G. Bernhardt, V. Christoffel, and A. Buschauer, “Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects,” Planta Medica, vol. 65, no. 6, pp. 512–516, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. M. K. Gharib Naseri, H. Mazlomi, M. Goshaiesh, G. Vakilzadeh, and A. Heidari, “Antispasmodic effect of Zataria multiflora Boiss. leaf extract on the rat uterus,” Iranian Journal of Pharmaceutical Research, vol. 5, no. 2, pp. 131–136, 2006. View at Google Scholar · View at Scopus
  29. M. Reiter and W. Brandt, “Relaxant effects on tracheal and ileal smooth muscles of the guinea pig,” Arzneimittelforschung, vol. 35, no. 1, pp. 408–414, 1985. View at Google Scholar · View at Scopus
  30. M. H. Boskabady, M. R. Aslani, and S. Kiani, “Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s),” Phytotherapy Research, vol. 20, no. 1, pp. 28–33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. H. Boskabady and H. Tabanfar, “Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains,” Indian Journal of Experimental Biology, vol. 49, no. 9, pp. 679–683, 2011. View at Google Scholar · View at Scopus
  32. M. H. Boskabady, Z. Jafari, and I. Pouraboli, “The effect of carvacrol on muscarinic receptors of guinea-pig tracheal chains,” Phytotherapy Research, vol. 25, no. 4, pp. 530–535, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. H. Boskabady, Z. Jafari, I. Pouraboli, B. Babazade, and M. G. Rahbardar, “Anti-cholinergic effect of Zataria multiflora Boiss. on guinea pig tracheal chains,” Natural Product Research, vol. 26, no. 16, pp. 1523–1528, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. Z. Jafari, M. H. Boskabady, I. Pouraboli, and B. Babazade, “Zataria multiflora Boiss. inhibited muscarinic receptors of incubated tracheal smooth muscle with propranolol,” Avicenna Journal of Phytomedicine, vol. 1, pp. 7–13, 2011. View at Google Scholar
  35. M. H. Boskabady, M. Kaveh, N. Eftekhar, and A. Nemati, “Zataria multiflora Boiss. and carvacrol affect β2-adrenoceptors of guinea pig trachea,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 857124, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. M. H. Boskabady, S. Shahmohammadi Mehrjardi, A. Rezaee, H. Rafatpanah, and S. Jalali, “The impactof Zataria multiflora Boiss. extracton in vitro and in vivo Th1/Th2 cytokine (IFN-γ/IL4) balance,” Journal of Ethnopharmacology, vol. 150, pp. 1024–1031, 2013. View at Google Scholar
  37. M. H. Boskabady and S. Jalali, “The effect of the extract of Zataria multiflora on total and differential WBC count and endothelin level in blood of ovalbumin sensitized guinea-pigs,” Chinese Journal of Integrative Medicine. In press.
  38. M. H. Boskabady and S. Jalali, “Effect of carvacrol on tracheal responsiveness, inflammatory mediators, total and differential WBC count in blood of sensitized guinea pigs,” Experimental Biology and Medicine, vol. 238, no. 2, pp. 200–208, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Jalali, M. H. Boskabady, A. Haeri-Rohani, and A. Eidi, “The effect of carvacrol on serum cytokines and endothelin levels of ovalbumin sensitized guinea-pigs,” Iranian Journal of Basic Medical Sciences, vol. 16, no. 4, pp. 615–619, 2013. View at Google Scholar · View at Scopus
  40. M. Babaie, N. Yasa, A. Mohammadirad, R. Khorasani, and M. Abdollahi, “On the anti oxidative stress potential of Zataria multiflora Boiss. (Avishan shirazi) in rats,” International Journal of Pharmacology, vol. 3, no. 6, pp. 510–514, 2007. View at Google Scholar · View at Scopus
  41. S. J. Hosseinimehr, S. Ahmadashrafi, F. Naghshvar, A. Ahmadi, S. Ehasnalavi, and M. Tanha, “Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells,” Integrative Cancer Therapies, vol. 9, no. 2, pp. 219–223, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. M. H. Boskabady and S. Kiani, “The effect of exposure of guinea pig to cigarette smoke and their sensitization in tracheal responsiveness to histamine and histamine receptor (h1) blockade by chlorpheniramine,” Pathophysiology, vol. 14, no. 2, pp. 97–104, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. M. H. Boskabady, S. Kiani, and M. R. Aslani, “Tracheal responsiveness to both isoprenaline and β2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs,” Respirology, vol. 11, no. 5, pp. 572–578, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. F. Khodabandehloo, M. Hosseini, Z. Rajaei, M. Soukhtanloo, E. Farrokhi, and M. Rezaeipour, “Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats,” Arquivos de Neuro-Psiquiatria, vol. 71, no. 5, pp. 313–319, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. E. F. Wouters, “Local and systemic inflammation in chronic obstructive pulmonary disease,” Proceedings of the American Thoracic Society, vol. 2, no. 1, pp. 26–33, 2005. View at Google Scholar
  46. J.-S. Li, Y. Li, S.-Y. Li et al., “Long-term effects of Tiaobu Feishen therapies on systemic and local inflammation responses in rats with stable chronic obstructive pulmonary disease,” Zhong Xi Yi Jie He Xue Bao, vol. 10, no. 9, pp. 1039–1048, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Kubo, M. Kobayashi, Y. Masunaga et al., “Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs,” European Respiratory Journal, vol. 26, no. 6, pp. 993–1001, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. A. D. Damiá, J. C. Gimeno, M. J. Ferrer, M. L. Fabregas, P. A. Folch, and J. M. Paya, “A study of the effect of proinflammatory cytokines on the epithelial cells of smokers, with or without COPD,” Archivos de Bronconeumologia, vol. 47, no. 9, pp. 447–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. W. Qamar and S. Sultana, “Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention,” Chemico-Biological Interactions, vol. 176, no. 2-3, pp. 79–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. L. M. A. Heunks, J. Viña, C. L. A. van Herwaarden, H. T. M. Folgering, A. Gimeno, and P. N. R. Dekhuijzen, “Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease,” The American Journal of Physiology, vol. 277, no. 6, pp. R1697–R1704, 1999. View at Google Scholar · View at Scopus
  51. H. Chen, M. J. Hansen, J. E. Jones et al., “Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss,” The American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 11, pp. 1248–1254, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. V. Mozzaffarian, A Dictionary of Iranian Plant Names, Farhang Moaser Publication, Tehran, Iran, 2nd edition, 1998.
  53. H. Afzali, M. Darabi, and M. Kashanian, “The effect of Zataria multiflora and Foeniculum vulgare in acute cough,” in Proceeding of the 16th Iranian Congresss of Physiology and Pharmacology, p. 19, Tabriz, Iran, 2003.
  54. J. Armstrong, C. Sargent, and D. Singh, “Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages,” Clinical and Experimental Immunology, vol. 158, no. 1, pp. 74–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. L. M. Kent, L. J. C. Smyth, J. Plumb et al., “Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N′-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504),” Journal of Pharmacology and Experimental Therapeutics, vol. 328, no. 2, pp. 458–468, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. S. V. Culpitt, D. F. Rogers, P. Shah et al., “Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease,” The American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 1, pp. 24–31, 2003. View at Publisher · View at Google Scholar · View at Scopus
  57. M.-H. Boskabady, R. Keyhanmanesh, S. Khameneh, Y. Doostdar, and M.-R. Khakzad, “Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs,” Journal of Zhejiang University: Science B, vol. 12, no. 3, pp. 201–209, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Byrami, M. H. Boskabady, S. Jalali, and T. Farkhondeh, “The effect of the extract of Crocus sativus on tracheal responsiveness and plasma levels of IL-4, IFN-γ, total NO and nitrite in ovalbumin sensitized guinea-pigs,” Journal of Ethnopharmacology, vol. 147, no. 2, pp. 530–535, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. J. Michiels, J. Missotten, N. Dierick, D. Fremaut, P. Maene, and S. de Smet, “In vitro degradation and in vivo passage kinetics of carvacrol, thymol, eugenol and trans-cinnamaldehyde along the gastrointestinal tract of piglets,” Journal of the Science of Food and Agriculture, vol. 88, no. 13, pp. 2371–2381, 2008. View at Publisher · View at Google Scholar · View at Scopus