Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS
Table 2
Hormonal, cytokine, and heat shock protein measurements by group (healthy subjects , SIRS , severe sepsis )∗∗.
Healthy subjects
SIRS
Severe sepsis
value*
Prolactin (ng/mL)
5.97 ± 2.80
18.26 ± 10.64a
23.17 ± 18.38b
0.003
Cortisol (g/dL)
12.07 ± 5.03
21.74 ± 16.09a
39.64 ± 23.52bc
0.000
ACTH (pg/mL)
25.97 ± 19.05
30.71 ± 69.54a
31.26 ± 25.18c
0.002
eHSP90 (ng/mL)
21.50 ± 10.08
58.70 ± 44.3a
81.89 ± 41.81bc
0.003
eHSP72 (ng/mL)
0.07 ± 0.06
0.35 ± 0.26a
1.43 ± 2.76b
0.005
iHSP90 (MFI)
49.73 ± 30.87
41.20 ± 31.62
37.36 ± 28.96
0.490
iHSP72 (MFI)
38.08 ± 24.76
36.65 ± 31.38
24.66 ± 21.15b
0.093
IL-6 (pg/mL)
1.70 ± 1.50
188.10 ± 203.92a
358.49 ± 377.40b
0.001
IL-10 (ng/mL)
0.01 ± 0.001
5.16 ± 7.10
35.29 ± 60.60b
0.037
IL-17 (ng/mL)
9.75 ± 16.65
20.86 ± 60.96
25.14 ± 93.56
0.969
IFN- (pg/mL)
0.52 ± 1.07
0.19 ± 0.10
0.92 ± 1.89c
0.070
eHSP: extracellular heat shock protein; iHSP: intracellular heat shock protein; IL: interleukins; IFN-: interferon gamma. between healthy subjects and SIRS groups. between healthy subjects and severe sepsis groups. between SIRS and severe sepsis group.
*The value was calculated using the Kruskal-Wallis test and a value <0.05 was considered statistically significant.
**Data are expressed as means ± SD (standard deviation).
