Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

Table 1

Clinical trials involving selected natural agents.

Natural agent	Trial identifier	Phase	Cancer type	Status
Curcumin	NCT01042938	2	Breast	Completed
	NCT00094445	2	Pancreatic	Completed
	NCT00192842	2	Pancreatic	Completed
	NCT01333917	1	Colorectal	Completed
	NCT00027495	1	Colorectal	Completed
	NCT01035580	1	Uterine cervical	Completed
	NCT00113841	n.a	Multiple myeloma	Completed
	NCT01975363	n.a	Breast	Active
	NCT01859858	1	Colorectal	Active
	NCT00745134	2	Rectal	Active
	NCT01294072	1	Colon	Active
	NCT01917890	n.a	Prostate	Active
	NCT01160302	0	Head and neck	Active
	NCT01490996	1/2	Colon	Active
	NCT02095717	2	Prostate	Active
	NCT02017353	2	Endometrial	Active
	NCT02064673	2	Prostate	Active
	NCT00641147	n.a	Familial adenomatous Polyposis	Active
	NCT00927485	n.a	Familial adenomatous Polyposis	Active
	NCT01948661	2	Colorectal	Active
Resveratrol	NCT00256334	1	Colon	Completed
	NCT00433576	1	Colorectal	Completed
	NCT00098969	1	Solid tumours	Completed
	NCT01476592	n.a	Neuroendocrine	Active
Genistein	NCT00244933	2	Breast	Completed
	NCT00118040	2	Bladder	Completed
	NCT00099008	1	Breast	Completed
	NCT00584532	2/3	Prostate	Completed
	NCT00376948	2	Pancreatic	Completed
	NCT00269555	n.a	Prostate	Completed
	NCT00499408	2	Prostate	Completed
	NCT00078923	2	Prostate	Completed
	NCT01985763	1/2	Colorectal	Active
	NCT01325311	2	Prostate	Active
	NCT01126879	2	Prostate	Active
	NCT01628471	1/2	Lung	Active
	NCT00276835	0	Kidney; melanoma	Active
	NCT01182246	1/2	Pancreatic	Active
EGCG	NCT00459407	1	Prostate	Completed
	NCT00233935	1	Esophageal	Completed
	NCT00573885	2	Lung	Completed
	NCT00303823	2	Cervical	Completed
	NCT01105338	2/3	Prostate	Completed
	NCT00516243	1	Breast	Active
	NCT00942422	2	Multiple myeloma	Active
	NCT00596011	2	Prostate	Active
	NCT01606124	2	Colorectal	Active
	NCT00253643	n.a	Prostate	Active
	NCT00917735	2	Breast	Active
	NCT01360320	2	Colorectal	Active
	NCT00949923	1	Breast	Active
I3C	NCT00607932	n.a	Prostate	Completed
	NCT00033345	1	Breast	Completed
	NCT00100958	1	Solid tumours	Completed
DIM	NCT00450229	1	Prostate	Completed
	NCT00305747	1	Prostate	Completed
	NCT00462813	3	Cervical	Completed
	NCT00888654	2	Prostate	Active
	NCT01391689	2/3	Breast	Active