Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

Table 2

Selected miRNAs targeting oncogenes.

Natural agent	miRNA	Regulation	Target(s) and function(s)	Cancer type	Reference
Curcumin	miR-181b	Up	Targets CXCL1 and CXCL2; inhibited migration through MMP	Breast	[41]
	miR-15a, miR-16	Up	miRNA inhibition upregulates Bcl-2 and WT1 and induces cell growth	Breast; leukemia	[42, 43]
	miR-203	Up	Targets Akt2 and Src; inhibits cell proliferation, invasion, and migration; and induces cell cycle arrest and apoptosis	Bladder	[44]
	miR-22	Up	Targets Erbb3; inhibits cell proliferation and migration	Pancreatic	[45]
Resveratrol	miR-663, miR-744	Up	Targets eEF1A; inhibits cell proliferation	Breast	[51]
	miR-21	Down	Upregulates Bcl-2; increases apoptosis	Pancreatic	[52]
	miR-622	Up	Targets K-Ras; inhibits proliferation and colony formation in vitro and tumorigenicity in vivo	Lung	[53]
Genistein	miR-34a	Up	Targets HOTAIR	Prostate	[54]
	miR-574-3p	Up	Targets RAC1, EGFR, and EP300; inhibits cell proliferation, migration, and invasion; and induces apoptosis	Prostate	[55]
	miR-1296	Up	miRNA inhibition upregulates MCM2 and vice versa	Prostate	[56]
EGCG	miR-16	Up	Targets Bcl-2	Hepatocellular	[57]
DIM	miR-21	Up	Targets Cdc25A	Pancreatic	[58]
	let-7 family	Up	Downregulates EZH2	Prostate	[59]
	miR-146	Up	Downregulates EGFR, IRAK-1, NF-kB, and MTA2; inhibits cell invasion	Pancreatic	[60]