Review Article
Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies
Table 4
Selected miRNAs targeting transcription factors.
| Natural agent | miRNA | Regulation | Target(s) and function(s) | Cancer type | Reference |
|
Curcumin | miR-22 | Up | miRNA inhibition upregulates SP1 and ESR1 expression and vice versa | Pancreatic | [78] | miR-27a, miR-20a, miR-17-5p | Down | Targets ZBTB4 and ZBTB10 | Colon | [79] |
|
Resveratrol | miR-34a | Up | Targets E2F3 | Colon | [80] | miR-520h | Down | Inhibits cell migration and invasion, decreases levels of FOXC2 | Lung | [81] | miR-663 | Up | Targets JunB and JunD; decreases miR-155 | Leukemia | [82] |
| DIM | miR-200 | Down | Targets ZEB1; downregulates ZEB1, slug, and vimentin; upregulates E-cadherin | Pancreatic | [83] |
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