Characterization of a Mycobacterium avium subsp. avium Operon Associated with Virulence and Drug Detoxification

Table 2

Drug susceptibility of MAA wild type and MAAΔlprG.

Drug	M. avium wild type	M. avium ΔlprG
INH^a	Resistant	Resistant
RIF^a	Resistant	Susceptible^c
LX^a	Resistant	Resistant
KAN^a	Susceptible	Susceptible
PNB^a	Resistant	Resistant
Determination of MIC (𝜇g/mL)
PAS^b	>8.0 (resistant)	>8.0 (resistant)
ETH^b	>8.0 (resistant)	>8.0 (resistant)
CS^b	120.0 (resistant)	120.0 (resistant)
CLA^b	0.5 (susceptible)	0.5 (susceptible)
AZ^b	1 (susceptible)	1 (susceptible)
AMK^b	8.0 (resistant)	4.0 (susceptible)^c
MOX^b	>1.0 (resistant)	1.0 (resistant)^c
LZ^b	2.0 (resistant)	0.5 (susceptible)^c
RBT^b	>2.0 (resistant)	0.25 (susceptible)^c

aDrug resistance was assayed using indirect proportion method on Middlebrook 7H11. ^bMICs were determined by the resazurin assay. ^cResitance values lower than those of the M. avium wild type strain.