Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma
Figure 2
Two PIK3CA “hotspot” mutations were identified in the six SDC patients by genomic DNA sequencing. A hotspot mutation of the PIK3CA gene (exon 20 nucleotide 3140 A → G substitution) was identified in patient SDC 2. Another hotspot mutation of PIK3CA (exon 9 nucleotide 1633 G → A alteration) was detected in SDC3. Both mutations were confirmed by antisense sequencing and sequencing of an independent PCR product from the original genomic template, and not noted in the adjacent normal tissues.
