Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats
Figure 6
Histological changes in brain cortex from (a) sham-operated, (b) empty noisome, (c) saline-treated, (d) free ascorbic acid, (e) ascorbic noisome, (f) α-tocopherol noisome, and (g) niosome formulation with a mixture of α-tocopherol and ascorbic acid in a ratio of 1 : 1 (w/w) treated rats. As shown in the figure, morphology of the neurons in sham-operated group is intact. Severe degenerative changes (dark nucleus and shrunken cytoplasm) are present in the saline-treated and empty noisome groups. These changes were less in the other groups, particularly in the niosomal formulation with a mixture of α-tocopherol and ascorbic acid. (Magnification ×400).
