BioMed Research International / 2014 / Article / Tab 1

Research Article

The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model

Table 1

The effect of synthetic substances (DEX, KET) and Valeriana officinalis on expression level of analyzed genes in male rats ().

Substance (mean% ± SEM%) 3 days (mean% ± SEM%) 10 days

CYP3A1
 DEX (50 mg/kg) 544.36 ± 34.07<0.001 # #
 KET (10 mg/kg)92.92 ± 4.070.381.97 ± 5.560.013
 VAL (300 mg/kg)65.37 ± 6.350.24863.36 ± 6.66<0.001
PXR
 DEX (50 mg/kg)118.72 ± 5.490.033 # #
 KET (10 mg/kg)101.27 ± 4.310.879105.52 ± 6.70.686
 VAL (300 mg/kg)103.66 ± 5.610.6296.35 ± 5.770.62
CAR
 DEX (50 mg/kg)68.85 ± 4.740.16 # #
 KET (10 mg/kg)97.14 ± 6.360.72138.44 ± 17.710.044
 VAL (300 mg/kg)99.0 ± 4.940.837146 ± 15.730.023
RXR
 DEX (50 mg/kg)117.79 ± 9.670.302 # #
 KET (10 mg/kg)67.34 ± 8.40.06160.63 ± 9.480.016
 VAL (300 mg/kg)71.39 ± 7.720.034101.19 ± 7.270.917
GR
 DEX (50 mg/kg)77.54 ± 4.050.008 # #
 KET (10 mg/kg)131.66 ± 5.680.00282.88 ± 10.040.145
 VAL (300 mg/kg)103.63 ± 6.780.644101.70 ± 7.210.859
HNF-4
 DEX (50 mg/kg)85.13 ± 9.460.196 # #
 KET (10 mg/kg)99.77 ± 15.620.987133.51 ± 7.650.047
 VAL (300 mg/kg)77.84 ± 3.920.00567.94 ± 7.370.012

The control groups fed standard diet were defined as 100%. as compared with the control group (one-way ANOVA test). DEX: Dexamethasone; KET: ketoconazole; VAL: Valeriana officinalis. #No data.