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1. D. Pan, G. M. Lanza, S. A. Wickline, and S. D. Caruthers, “Nanomedicine: perspective and promises with ligand-directed molecular imaging,” European Journal of Radiology, vol. 70, no. 2, pp. 274–285, 2009. View at Publisher · View at Google Scholar · View at Scopus
2. E. A. Osborn and F. A. Jaffer, “Advances in molecular imaging of atherosclerotic vascular disease,” Current Opinion in Cardiology, vol. 23, no. 6, pp. 620–628, 2008. View at Publisher · View at Google Scholar · View at Scopus
3. R. Weissleder and M. J. Pittet, “Imaging in the era of molecular oncology,” Nature, vol. 452, no. 7187, pp. 580–589, 2008. View at Publisher · View at Google Scholar · View at Scopus
4. R. Atreya and M. Goetz, “Molecular imaging in gastroenterology,” Nature Reviews Gastroenterology & Hepatology, vol. 10, no. 12, pp. 704–7712, 2013. View at Google Scholar
5. S. E. P. New and E. Aikawa, “Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification,” Circulation Research, vol. 108, no. 11, pp. 1381–1391, 2011. View at Publisher · View at Google Scholar · View at Scopus
6. C. M. Gomes, A. J. Abrunhosa, P. Ramos, and E. K. J. Pauwels, “Molecular imaging with SPECT as a tool for drug development,” Advanced Drug Delivery Reviews, vol. 63, no. 7, pp. 547–554, 2011. View at Publisher · View at Google Scholar · View at Scopus
7. A. T. Byrne, A. E. O'Connor, M. Hall et al., “Vascular-targeted photodynamic therapy with BF2-chelated tetraaryl-azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment,” British Journal of Cancer, vol. 101, no. 9, pp. 1565–1573, 2009. View at Publisher · View at Google Scholar · View at Scopus
8. S. Luo, E. Zhang, Y. Su, T. Cheng, and C. Shi, “A review of NIR dyes in cancer targeting and imaging,” Biomaterials, vol. 32, no. 29, pp. 7127–7138, 2011. View at Publisher · View at Google Scholar · View at Scopus
9. M. L. James and S. S. Gambhir, “A molecular imaging primer: modalities, imaging agents, and applications,” Physiological Reviews, vol. 92, no. 2, pp. 897–965, 2012. View at Publisher · View at Google Scholar · View at Scopus
10. K. Chen and X. Chen, “Design and development of molecular imaging probes,” Current Topics in Medicinal Chemistry, vol. 10, no. 12, pp. 1227–1236, 2010. View at Publisher · View at Google Scholar · View at Scopus
11. C. J. Anderson and R. Ferdani, “Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research,” Cancer Biotherapy and Radiopharmaceuticals, vol. 24, no. 4, pp. 379–393, 2009. View at Publisher · View at Google Scholar · View at Scopus
12. J. Yuan, H. Zhang, H. Kaur et al., “Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography,” Molecular Imaging, vol. 12, no. 3, pp. 203–212, 2012. View at Google Scholar
13. C. Xavier, I. Vaneycken, M. D'huyvetter et al., “Synthesis, preclinical validation, dosimetry, and toxicity of 68Ga-NOTA-Anti-HER2 nanobodies for iPET imaging of HER2 receptor expression in cancer,” The Journal of Nuclear Medicine, vol. 54, no. 5, pp. 776–784, 2013. View at Google Scholar
14. M. E. Phelps, “Positron emission tomography provides molecular imaging of biological processes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 16, pp. 9226–9233, 2000. View at Publisher · View at Google Scholar · View at Scopus
15. A. Afshar-Oromieh, U. Haberkorn, M. Eder, M. Eisenhut, and C. Zechmann, “PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 40, no. 4, pp. 486–495, 2013. View at Publisher · View at Google Scholar · View at Scopus
16. A. J. Beer, H. Kessler, H. J. Wester et al., “PET imaging of integrin α3βv expression,” Theranosttiics, vol. 1, pp. 48–57, 2011. View at Google Scholar
17. B. J. Pichler, M. S. Judenhofer, and C. Pfannenberg, “Multimodal imaging approaches: PET/CT and PET/MRI—part 1,” Handbook of Experimental Pharmacology, no. 185, pp. 109–132, 2008. View at Google Scholar · View at Scopus
18. D. Belkić and K. Belkić, “Molecular imaging in the framework of personalized cancer medicine,” The Israel Medical Association Journal, vol. 15, pp. 665–672, 2013. View at Google Scholar
19. W. P. Andrade, E. N. Lima, C. A. Osório et al., “Can FDG-PET/CT predict early response to neoadjuvant chemotherapy in breast cancer?” European Journal of Surgical Oncology, vol. 39, no. 12, pp. 1358–1363, 2013. View at Google Scholar
20. P. Blake, B. Johnson, and J. W. VanMeter, “Positron emission tomography (PET) and single photon emission computed tomography (SPECT): clinical applications,” Journal of Neuro-Ophthalmology, vol. 23, no. 1, pp. 34–41, 2003. View at Publisher · View at Google Scholar · View at Scopus
21. A. M. Catafau and S. Bullich, “Molecular imaging PET and SPECT approaches for improving productivity of antipsychotic drug discovery and development,” Current Medicinal Chemistry, vol. 20, no. 3, pp. 378–388, 2013. View at Google Scholar
22. M. Benadiba, G. Luurtsema, and L. Wichert-Ana, “New molecular targets for PET and SPECT imaging in neurodegenerative diseases,” Revista Brasileira de Psiquiatria, vol. 34, supplement 2, pp. S125–S148, 2012. View at Google Scholar
23. N. M. Hijnen, A. de Vries, K. Nicolay, and H. Grüll, “Dual-isotope111In/177Lu SPECT imaging as a tool in molecular imaging tracer design,” Contrast Media and Molecular Imaging, vol. 7, no. 2, pp. 214–222, 2012. View at Publisher · View at Google Scholar · View at Scopus
24. S. Hapdey, M. Soret, and I. Buvat, “Quantification in simultaneous 99mTc/123I brain SPECT using generalized spectral factor analysis: a Monte Carlo study,” Physics in Medicine and Biology, vol. 51, no. 23, pp. 6157–6171, 2006. View at Publisher · View at Google Scholar · View at Scopus
25. A. M. Blamire, “The technology of MRI: the next 10 years?” British Journal of Radiology, vol. 81, no. 968, pp. 601–617, 2008. View at Publisher · View at Google Scholar · View at Scopus
26. J. C. Gore, H. C. Manning, C. C. Quarles, K. W. Waddell, and T. E. Yankeelov, “Magnetic resonance in the era of molecular imaging of cancer,” Magnetic Resonance Imaging, vol. 29, no. 5, pp. 587–600, 2011. View at Publisher · View at Google Scholar · View at Scopus
27. P. L. Rapley, C. Witiw, K. Rich et al., “In vitro molecular magnetic resonance imaging detection and measurement of apoptosis using superparamagnetic iron oxide + antibody as ligands for nucleosomes,” Physics in Medicine and Biology, vol. 57, no. 21, pp. 7015–7028, 2012. View at Google Scholar
28. I. Debergh, N. Van Damme, D. De Naeyer et al., “Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ 3 integrin,” Annals of Surgical Oncology, 2013. View at Publisher · View at Google Scholar
29. S. Sawall, J. Kuntz, M. Socher et al., “Imaging of cardiac perfusion of free-breathing small animals using dynamic phase-correlated micro-CT,” Medical Physics, vol. 39, no. 12, pp. 7499–7506, 2012. View at Google Scholar
30. S. M. Johnston, G. A. Johnson, and C. T. Badea, “Temporal and spectral imaging with micro-CT,” Medical Physics, vol. 39, no. 8, pp. 4943–4958, 2012. View at Google Scholar
31. J. Schaap, J. A. de Groot, K. Nieman et al., “Hybrid myocardial perfusion SPECT/CT coronary angiography and invasive coronary angiography in patients with stable angina pectoris lead to similar treatment decisions,” Heart, vol. 99, no. 3, pp. 188–194, 2013. View at Google Scholar
32. R. Popovtzer, A. Agrawal, N. A. Kotov et al., “Targeted gold nanoparticles enable molecular CT imaging of cancer,” Nano Letters, vol. 8, no. 12, pp. 4593–4596, 2008. View at Publisher · View at Google Scholar · View at Scopus
33. F. Hyafil, J.-C. Cornily, J. E. Feig et al., “Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography,” Nature Medicine, vol. 13, no. 5, pp. 636–641, 2007. View at Publisher · View at Google Scholar · View at Scopus
34. D. Pan, T. A. Williams, A. Senpan et al., “Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle,” Journal of the American Chemical Society, vol. 131, no. 42, pp. 15522–15527, 2009. View at Publisher · View at Google Scholar · View at Scopus
35. J. Li, A. Chaudhary, S. J. Chmura et al., “A novel functional CT contrast agent for molecular imaging of cancer,” Physics in Medicine and Biology, vol. 55, no. 15, pp. 4389–4397, 2010. View at Publisher · View at Google Scholar · View at Scopus
36. M. Rotman, T. J. A. Snoeks, and L. van der Weerd, “Pre-clinical optical imaging and MRI for drug development in Alzheimer's disease,” Drug Discovery Today, vol. 8, no. 2–4, pp. e117–e125, 2011. View at Publisher · View at Google Scholar · View at Scopus
37. L. E. Edgington, A. B. Berger, G. Blum et al., “Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes,” Nature Medicine, vol. 15, no. 8, pp. 967–973, 2009. View at Publisher · View at Google Scholar · View at Scopus
38. G. Niu, L. Zhu, D. N. Ho et al., “Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosis,” Theranostics, vol. 3, no. 3, pp. 190–200, 2013. View at Google Scholar
39. R. Atreya, M. J. Waldner, and M. F. Neurath, “Molecular imaging: interaction between basic and clinical science,” Gastroenterology Clinics of North America, vol. 39, no. 4, pp. 911–922, 2010. View at Publisher · View at Google Scholar · View at Scopus
40. J. Bzyl, W. Lederle, M. Palmowski, and F. Kiessling, “Molecular and functional ultrasound imaging of breast tumors,” European Journal of Radiology, vol. 81, supplement 1, pp. S11–S12, 2012. View at Google Scholar
41. N. Deshpande, A. Needles, and J. K. Willmann, “Molecular ultrasound imaging: current status and future directions,” Clinical Radiology, vol. 65, no. 7, pp. 567–581, 2010. View at Publisher · View at Google Scholar · View at Scopus
42. P. Li, Y. Zheng, H. Ran et al., “Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice,” Journal of Controlled Release, vol. 162, no. 2, pp. 349–354, 2012. View at Google Scholar
43. J. T. Sutton, K. J. Haworth, G. Pyne-Geithman, and C. K. Holland, “Ultrasound-mediated drug delivery for cardiovascular disease,” Expert Opinion on Drug Delivery, vol. 10, no. 5, pp. 573–592, 2013. View at Google Scholar
44. M. Mancini, A. Greco, G. Salvatore et al., “Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice,” BMC Medical Imaging, vol. 13, article 31, 2013. View at Publisher · View at Google Scholar
45. P. Li, Y. Zheng, H. Ran et al., “Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice,” Journal of Controlled Release, vol. 162, no. 2, pp. 349–354, 2012. View at Google Scholar
46. Z.-Y. Chen, K. Liang, and R. X. Qiu, “Targeted gene delivery in tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosis,” Journal of Experimental and Clinical Cancer Research, vol. 29, no. 1, pp. 1–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
47. W. Cai and X. Chen, “Nanoplatforms for targeted molecular imaging in living subjects,” Small, vol. 3, no. 11, pp. 1840–1854, 2007. View at Publisher · View at Google Scholar · View at Scopus
48. Y. Lin, Z. Y. Chen, and F. Yang, “Ultrasound-based multimodal molecular imaging and functional ultrasound contrast agents,” Current Pharmaceutical Design, vol. 19, no. 18, pp. 3342–3351, 2013. View at Google Scholar
49. T. D. Poeppel, B. J. Krause, T. A. Heusner, C. Boy, A. Bockisch, and G. Antoch, “PET/CT for the staging and follow-up of patients with malignancies,” European Journal of Radiology, vol. 70, no. 3, pp. 382–392, 2009. View at Publisher · View at Google Scholar · View at Scopus
50. W. Cai, G. Niu, and X. Chen, “Multimodality imaging of the HER-kinase axis in cancer,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 35, no. 1, pp. 186–208, 2008. View at Publisher · View at Google Scholar · View at Scopus
51. W. Cai and X. Chen, “Multimodality molecular imaging of tumor angiogenesis,” The Journal of Nuclear Medicine, vol. 49, supplement 2, pp. 113S–128S, 2008. View at Google Scholar
52. Z. S. Browning, A. A. Wilkes, D. S. Mackenzie et al., “Using PET/CT imaging to characterize 18 F-fluorodeoxyglucose utilization in fish,” Journal of Fish Diseases, vol. 36, no. 11, pp. 911–919, 2013. View at Google Scholar
53. R. Abgral, S. Querellou, G. Potard et al., “Does 18F-FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up?” Journal of Nuclear Medicine, vol. 50, no. 1, pp. 24–29, 2009. View at Publisher · View at Google Scholar · View at Scopus
54. W. W. Lee, B. Marinelli, A. M. Van Der Laan et al. et al., “PET/MRI of inflammation in myocardial infarction,” Journal of the American College of Cardiology, vol. 59, no. 2, pp. 153–163, 2012. View at Publisher · View at Google Scholar · View at Scopus
55. A. Kjær, A. Loft, I. Law et al., “PET/MRI in cancer patients: first experiences and vision from Copenhagen,” Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 26, no. 1, pp. 37–47, 2012. View at Google Scholar
56. B. Li, M. Abran, C. Matteau-Pelletier et al., “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” Journal of Biomedical Optics, vol. 16, no. 12, Article ID 126010, 2011. View at Google Scholar · View at Scopus
57. P. Agrawal, G. J. Strijkers, and K. Nicolay, “Chitosan-based systems for molecular imaging,” Advanced Drug Delivery Reviews, vol. 62, no. 1, pp. 42–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
58. M. A. McDonald, P. C. Wang, and E. L. Siegel, “Protein nanospheres: synergistic nanoplatform-based probes for multimodality imaging,” in Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, Proceedings of SPIE, San Francisco, Calif, USA, January 2011. View at Publisher · View at Google Scholar · View at Scopus
59. G. D. Kenny, N. Kamaly, T. L. Kalber et al., “Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo,” Journal of Controlled Release, vol. 149, no. 2, pp. 111–116, 2011. View at Publisher · View at Google Scholar · View at Scopus
60. L. Evangelista, A. R. Cervino, S. Chondrogiannis et al., “Comparison between anatomical cross-sectional imaging and 18F-FDG PET/CT in the staging, restaging, treatment response, and long-term surveillance of squamous cell head and neck cancer: a systematic literature overview,” Nuclear Medicine Communications, vol. 35, no. 2, pp. 123–134, 2014. View at Google Scholar
61. B. X. Ren, F. Yang, G. H. Zhu et al., “Magnetic resonance tumor targeting imaging using gadolinium labeled human telomerase reverse transcriptase antisense probes,” Cancer Science, vol. 103, no. 8, pp. 1434–1439, 2012. View at Google Scholar
62. J. Gao and H. Zheng, “Illuminating the lipidome to advance biomedical research: peptide-based probes of membrane lipids,” Future Medicinal Chemistry, vol. 5, no. 8, pp. 947–959, 2013. View at Google Scholar
63. L. Hansen, E. K. Unmack Larsen, E. H. Nielsen et al., “Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells,” Nanoscale, vol. 5, no. 17, pp. 8192–8201, 2013. View at Google Scholar
64. B. J. Hackel, R. H. Kimura, and Z. Miao, “18F-Fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin $\alpha \text{v}\beta \text{6}$,” Nanoscale, vol. 55, no. 7, pp. 1101–1105, 2013. View at Google Scholar
65. S. Oliveira, R. Heukers, J. Sornkom, R. J. Kok, and P. M. van Bergen en Henegouwen, “Targeting tumors with nanobodies for cancer imaging and therapy,” Journal of Controlled Release, vol. 172, no. 3, pp. 607–617, 2013. View at Google Scholar
66. Y. Zhang, H. Hong, and H. Orbay, “PET imaging of CD105/endoglin expression with a ^61/64Cu-labeled Fab antibody fragment,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 40, no. 5, pp. 759–767, 2013. View at Google Scholar
67. M. Abdolahi, D. Shahbazi-Gahrouei, S. Laurent et al., “Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer,” Contrast Media & Molecular Imaging, vol. 8, no. 2, pp. 175–184, 2013. View at Google Scholar
68. P. R. Bouchard, R. M. Hutabarat, and K. M. Thompson, “Discovery and development of therapeutic aptamers,” Annual Review of Pharmacology and Toxicology, vol. 50, pp. 237–257, 2010. View at Publisher · View at Google Scholar · View at Scopus
69. A. D. Keefe, S. Pai, and A. Ellington, “Aptamers as therapeutics,” Nature Reviews Drug Discovery, vol. 9, no. 7, pp. 537–550, 2010. View at Publisher · View at Google Scholar · View at Scopus
70. H. Hong, S. Goel, Y. Zhang, and W. Cai, “Molecular imaging with nucleic acid aptamers,” Current Medicinal Chemistry, vol. 18, no. 27, pp. 4195–4205, 2011. View at Publisher · View at Google Scholar · View at Scopus
71. H. Shi, X. He, K. Wang et al., “Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 10, pp. 3900–3905, 2011. View at Publisher · View at Google Scholar · View at Scopus
72. V. Bagalkot, L. Zhang, E. Levy-Nissenbaum et al., “Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer,” Nano Letters, vol. 7, no. 10, pp. 3065–3070, 2007. View at Publisher · View at Google Scholar · View at Scopus
73. D. W. Hwang, H. Y. Ko, J. H. Lee et al., “A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer,” Journal of Nuclear Medicine, vol. 51, no. 1, pp. 98–105, 2010. View at Publisher · View at Google Scholar · View at Scopus
74. A. Louie, “Multimodality imaging probes: design and challenges,” Chemical Reviews, vol. 110, no. 5, pp. 3146–3195, 2010. View at Publisher · View at Google Scholar · View at Scopus
75. M. A. Hall, S. Kwon, H. Robinson et al., “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate, vol. 72, no. 2, pp. 129–146, 2012. View at Publisher · View at Google Scholar · View at Scopus
76. S. Y. Madani, F. Shabani, M. V. Dwek et al., “Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment,” International Journal of Nanomedicine, vol. 8, pp. 941–950, 2013. View at Google Scholar
77. R. John, F. T. Nguyen, K. J. Kolbeck et al., “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Molecular Imaging and Biology, vol. 14, pp. 17–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
78. J. Ma, P. Huang, M. He et al., “Folic acid-conjugated LaF3:Yb,Tm@SiO2 nanoprobes for targeting dual-modality imaging of upconversion luminescence and X-ray computed tomography,” The Journal of Physical Chemistry B, vol. 116, no. 48, pp. 14062–14070, 2012. View at Google Scholar
79. Z. Liu, T. Lammers, J. Ehling et al., “Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging,” Biomaterials, vol. 32, no. 26, pp. 6155–6163, 2011. View at Publisher · View at Google Scholar · View at Scopus
80. M. Liang, X. Liu, D. Cheng et al., “Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle,” Bioconjugate Chemistry, vol. 21, no. 7, pp. 1385–1388, 2010. View at Publisher · View at Google Scholar · View at Scopus
81. J. K. Willmann, Z. Cheng, C. Davis et al., “Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-pet in mice,” Radiology, vol. 249, no. 1, pp. 212–219, 2008. View at Publisher · View at Google Scholar · View at Scopus
82. N. Deshpande, A. Needles, and J. K. Willmann, “Molecular ultrasound imaging: current status and future directions,” Clinical Radiology, vol. 65, no. 7, pp. 567–581, 2010. View at Publisher · View at Google Scholar · View at Scopus
83. F. Yan, X. Li, Q. Jin et al., “Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide: preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells,” Ultrasound in Medicine and Biology, vol. 37, no. 5, pp. 768–779, 2011. View at Publisher · View at Google Scholar · View at Scopus