Mp-MRI targeted TRUS-G biopsy of clinically significant prostate cancer. 66-year-old patient with a PSA of 8 ng/mL. Prebiopsy mp-MRI (a) shows a 9 mm low T2 nodule (image (a); upper row), with high retriction of water diffusion and hypervascularization (image (a); lower row) in the anterior horn of the right apical PZ, ahead of the posterior 18 mm of gland sampled by SB cores. A TB was performed with knowledge of this information. It diagnosed a CSPCa (4 out of 4 positive TB; no SB was positive). Image (b) shows the trace of the needle biopsy gun inside the nodule. This lesion was aimed with visual registration, thanks to its zonal anatomy (ahead of the anterior TZ, at the edge of the anterior prostate surface), its size, and the presence of a small cyst in the right TZ (not visible on image (b), but used to locate the craniocaudal location of the lesion at time of biopsy).