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BioMed Research International
Volume 2014, Article ID 823879, 10 pages
http://dx.doi.org/10.1155/2014/823879
Research Article

Impact of Gentamicin Coadministration along with High Fructose Feeding on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley Rats

1Department of Pharmacology and Toxicology, School of Medicine and Health Science, Universiti Putra Malaysia, 47300 Serdang, Selangor, Malaysia
2Department of Clinical Laboratory Science, Faculty of Pharmacy, Baghdad University, Baghdad, Iraq
3Department of Anatomy, School of Medicine and Health Science, Universiti Putra Malaysia, 47300 Serdang, Selangor, Malaysia
4Department of Veterinary Surgery, School of Veterinary Medicine, Universiti Putra Malaysia, 47300 Serdang, Selangor, Malaysia
5Department of Pathology, School of Medicine and Health Science, Universiti Putra Malaysia, 47300 Serdang, Selangor, Malaysia
6Department of Pathology, School of Dentistry, Universiti Technology MARA, 48600 Shah Alam, Selangor, Malaysia

Received 13 February 2014; Revised 24 April 2014; Accepted 3 May 2014; Published 23 June 2014

Academic Editor: Emmanuel A. Burdmann

Copyright © 2014 Zaid O. Ibraheem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Lopez-Novoa, Y. Quiros, L. Vicente, A. I. Morales, and F. J. Lopez-Hernandez, “New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view,” Kidney International, vol. 79, no. 1, pp. 33–45, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Cojocel, N. Dociu, K. Maita, S. D. Sleight, and J. B. Hook, “Effects of aminoglycosides on glomerular permeability, tubular reabsorption, and intracellular catabolism of the cationic low-molecular-weight protein lysozyme,” Toxicology and Applied Pharmacology, vol. 68, no. 1, pp. 96–109, 1983. View at Google Scholar · View at Scopus
  3. M.-P. Mingeot-Leclercq and P. M. Tulkens, “Aminoglycosides: nephrotoxicity,” Antimicrobial Agents and Chemotherapy, vol. 43, no. 5, pp. 1003–1012, 1999. View at Google Scholar · View at Scopus
  4. J. Hallfrisch, “Metabolic effects of dietary fructose,” The FASEB Journal, vol. 4, no. 9, pp. 2652–2660, 1990. View at Google Scholar · View at Scopus
  5. F. J. Martinez, R. A. Rizza, and J. C. Romero, “High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs,” Hypertension, vol. 23, no. 4, pp. 456–463, 1994. View at Google Scholar · View at Scopus
  6. M. J. Dekker, Q. Su, C. Baker, A. C. Rutledge, and K. Adeli, “Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 299, no. 5, pp. E685–E694, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. R. M. N. Bezerra, M. Ueno, M. S. Silva, D. Q. Tavares, C. R. Carvalho, and M. J. Saad, “A high fructose diet affects the early steps of insulin action in muscle and liver of rats,” Journal of Nutrition, vol. 130, no. 6, pp. 1531–1535, 2000. View at Google Scholar · View at Scopus
  8. Z. O. Ibraheem, M. A. Sattar, N. A. Abdullah et al., “The effect of acute experimental nephrotoxicity on the progression of metabolic and cardiovascular abnormalities in a rat model of saturated free fatty acid-induced metabolic syndrome,” Advances in Clinical and Experimental Medicine, vol. 20, no. 6, pp. 667–676, 2011. View at Google Scholar · View at Scopus
  9. S. Noori, “Effect of Cocoa Powder on Oxidant/antioxidant status in liver, heart and kidney tissues of rats,” The Journal of Animal & Plant Sciences, vol. 19, no. 4, pp. 174–178, 2009. View at Google Scholar
  10. N. E. Reiner, D. D. Bloxham, and W. L. Thompson, “Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs,” Journal of Antimicrobial Chemotherapy, vol. 4, supplement A, pp. 85–101, 1978. View at Google Scholar · View at Scopus
  11. S. S. Elliott, N. L. Keim, J. S. Stern, K. Teff, and P. J. Havel, “Fructose, weight gain, and the insulin resistance syndrome,” The American Journal of Clinical Nutrition, vol. 76, no. 5, pp. 911–922, 2002. View at Google Scholar · View at Scopus
  12. D. L. Curry, “Effects of mannose and fructose on the synthesis and secretion of insulin,” Pancreas, vol. 4, no. 1, pp. 2–9, 1989. View at Google Scholar · View at Scopus
  13. K. L. Teff, J. Grudziak, R. R. Townsend et al., “Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 5, pp. 1562–1569, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. N. Faria, F. F. Ribeiro Filho, S. R. Gouveia Ferreira, and M. T. Zanella, “Impact of visceral fat on blood pressure and insulin sensitivity in hypertensive obese women,” Obesity Research, vol. 10, no. 12, pp. 1203–1206, 2002. View at Google Scholar · View at Scopus
  15. G. Kanuri, A. Spruss, S. Wagnerberger, S. C. Bischoff, and I. Bergheim, “Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice,” Journal of Nutritional Biochemistry, vol. 22, no. 6, pp. 527–534, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Wei, D. Wang, and M. J. Pagliassotti, “Fructose selectively modulates c-jun N-terminal kinase activity and insulin signaling in rat primary hepatocytes,” Journal of Nutrition, vol. 135, no. 7, pp. 1642–1646, 2005. View at Google Scholar · View at Scopus
  17. N. Roglans, L. Vilà, M. Farré et al., “Impairment of hepatic STAT-3 activation and reduction of PPARα activity in fructose-fed rats,” Hepatology, vol. 45, no. 3, pp. 778–788, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-W. Tan, S.-S. Xing, X.-P. Bi et al., “Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-κB activation,” Acta Pharmacologica Sinica, vol. 29, no. 9, pp. 1051–1059, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Roglans, E. Sanguino, C. Peris et al., “Atorvastatin treatment induced peroxisome proliferator-activated receptor α expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 302, no. 1, pp. 232–239, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Shapiro, W. Mu, C. Roncal, K.-Y. Cheng, R. J. Johnson, and P. J. Scarpace, “Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 295, no. 5, pp. R1370–R1375, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Grunfeld, M. Gimenez, M. Balzaretti, L. Rabinovich, M. Romo, and R. Simsolo, “Insulin effect on renal sodium reabsorption in adolescent offspring of essential hypertensive parents,” Hypertension, vol. 26, no. 6, pp. 1089–1092, 1995. View at Google Scholar · View at Scopus
  22. H. Herlitz, B. Widgren, V. Urbanavicius, S. Attvall, and B. Persson, “Stimulatory effect of insulin on tubular sodium reabsorption in normotensive subjects with a positive family history of hypertension,” Nephrology Dialysis Transplantation, vol. 11, no. 1, pp. 47–54, 1996. View at Google Scholar · View at Scopus
  23. T. Nakagawa, K. R. Tuttle, R. A. Short, and R. J. Johnson, “Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome,” Natural Clinical Practice and Nephrology, vol. 1, no. 2, pp. 80–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. G. K. Glantzounis, E. C. Tsimoyiannis, A. M. Kappas, and D. A. Galaris, “Uric acid and oxidative stress,” Current Pharmaceutical Design, vol. 11, no. 32, pp. 4145–4151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Wei, D. Wang, G. Moran, A. Estrada, and M. J. Pagliassotti, “Fructose-induced stress signaling in the liver involves methylglyoxal,” Nutrition and Metabolism, vol. 10, no. 1, article 32, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Guo, W. Ren, A. Li et al., “Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease,” Digestive Diseases and Sciences, vol. 58, no. 4, pp. 1004–1009, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Levi and M. J. Werman, “Long-term fructose consumption accelerates glycation and several age-related variables in male rats,” Journal of Nutrition, vol. 128, no. 9, pp. 1442–1449, 1998. View at Google Scholar · View at Scopus
  28. G. Bledsoe, B. Shen, Y.-Y. Yao et al., “Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury,” Toxicological Sciences, vol. 102, no. 2, pp. 433–443, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M.-C. Zennaro, M. Caprio, and B. Fève, “Mineralocorticoid receptors in the metabolic syndrome,” Trends in Endocrinology and Metabolism, vol. 20, no. 9, pp. 444–451, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. L. Rodrigues, M. P. Baldo, R. de Sá Cunha et al., “Salt excretion in normotensive individuals with metabolic syndrome: a population-based study,” Hypertension Research, vol. 32, no. 10, pp. 906–910, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Elliott, N. Newman, and A. Madan, “Gentamicin effects on urinary electrolyte excretion in healthy subjects,” Clinical Pharmacology and Therapeutics, vol. 67, no. 1, pp. 16–21, 2000. View at Google Scholar · View at Scopus