Research Article

Impact of Gentamicin Coadministration along with High Fructose Feeding on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley Rats

Table 3

Metabolic syndrome assessment parameters.

ParameterTime ControlFF2FGG

F glu
mmol/L
d03.8 ± 0.185.6 ± 0.25*5.5 ± 0.30*5.8 ± 0.22*3.7 ± 0.19
d204.4 ± 0.185.9 ± 0.16*6.1 ± 0.23*6.7 ± 0.19*4.2 ± 0.18

Serum cholesterol
mmol/L
d00.87 ± 0.081.17 ± 0.051.18 ± 0.091.24 ± 0.090.84 ± 0.08
d200.92 ± 0.07 1.19 ± 0.07 1.24 ± 0.06 1.37 ± 0.13* 0.77 ± 0.09

Serum triglyceride
mmol/L
d00.65 ± 0.11.27 ± 0.15*1.30 ± 0.12*1.32 ± 0.11*0.84 ± 0.08
d200.70 ± 0.131.24 ± 0.10*1.29 ± 0.14*1.67 ± 0.14*0.77 ± 0.09

Serum insulin
μ I.U/mL
d024.2 ± 1.923.3 ± 1.925.2 ± 1.725.2 ± 1.726.4 ± 1.9
d2026.2 ± 2.129.4 ± 2.331.3 ± 1.9*38.3 ± 1.9*24.1 ± 2.1

Obesity index d202.04 ± 0.13 2.75 ± 0.22*@2.74 ± 0.21*@3.14 ± 0.21*@

Serum parameters measurements were taken on days 0 and 20 of gentamicin therapy which correspond to the 38th and the 58th days of the high fructose water treatment period. Obesity index was measured at the end of the treatment period. Results are expressed in mean ± SEM. *, ‡, #, $, and @ indicate statistical significance as compared to control, F, F2, FG, and G groups, respectively ( ).