Research Article

Impact of Gentamicin Coadministration along with High Fructose Feeding on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley Rats

Table 5

Oxidative stress parameters (malondialdehyde (MDA) and glutathione) in both serum and renal homogenates.

ParameterControlF2FGG

Oxidative stress in serum at the end of the treatment period (day 24)
 Serum MDA nmol/mL 2.735 ± 0.163.46 ± 0.325.783 ± 0.31*2.86 ± 0.19
 Serum glutathione (GSH) mL/L167 ± 5.23145 ± 5.8103 ± 4.9*159 ± 6.3
Oxidative stress in kidney homogenate at the end of the treatment period
 MDA in nmol/g kidney tissue65.4 ± 2.367.1 ± 2.683.2 ± 3.779.4 ± 5.8
 GSH glutathione mg/g kidney tissue 98.5 ± 3.197.5 ± 2.889.5 ± 3.291.2 ± 2.6

The measurements were done at the end of the treatment period. Results are expressed as mean ± S.E.M. *, ‡, $, and @ indicate statistical significance as compared to control, F2, FG, and G groups, respectively ( ).