Intraoperative Assessment of Surgical Margins of Oral Squamous Cell Carcinoma Using Frozen Sections: A Practical Clinicopathological Management for Recurrences

Table 3

Additional surgery according to FS and final histopathology at margins of surgical specimens.

Clinical outcomes	FS		(%)	Borderline malignancies recognized by FS		(%)	Additional Surgery according to FS		(%)	Final histopathological diagnoses at surgical margin
										SCC	(%)	CIS	(%)	Epithelial dysplasia				Normal	(%)
														Moderate	(%)	Mild	(%)
Relapse-free (𝑛=191)	Yes	128	(67.0)	Yes	55	(43.0)	Yes	38	(69.1)	2	(5.3)	6	(15.8)	12	(31.6)	18	(47.3)	0	(0.0)
							No	17	(30.9)	0	(0.0)	3	(17.6)	8	(47.1)	5	(29.4)	1	(5.9)
				No	73	(57.0)	—	—	—	1	(1.4)	1	(1.4)	11	(15.0)	57	(78.1)	3	(4.1)
	No	63	(33.0)	—	—	—	—	—	—	0	(0.0)	8	(12.7)	33	(52.4)	22	(34.9)	0	(0.0)
Relapse (𝑛=152)	yes	83	(54.6)	Yes	57	(68.7)	Yes	39	(68.4)	6	(15.4)	17	(43.6)	13	(33.3)	3	(7.7)	0	(0.0)
							No	18	(31.6)	3	(16.7)	9	(50.0)	6	(33.3)	0	(0.0)	0	(0.0)
				No	26	(31.3)	—	—	—	4	(15.4)	6	(23.1)	8	(30.8)	7	(26.9)	1	(3.8)
	No	69	(45.4)	—	—	—	—	—	—	10	(14.5)	32	(46.4)	13	(18.8)	13	(18.8)	1	(1.5)