Progress in the Identification of Dengue Virus Entry/Fusion Inhibitors
Schematic representation of the dengue virus entry process and possible antiviral targets. The dengue virus makes use of cellular membrane receptors and attachment factors to find its way to the cytoplasm. First, the mature virion gets attached to a cellular membrane receptor (a). It is not clear whether single interactions or sequential usage of several molecules is required to trigger the endocytic, clathrin-dependent pathway (b). The endocytic vesicle becomes a late endosome (c), where acidification triggers conformational changes on the E protein dimers to become fusogenic trimers. Finally, pores are formed and the genome of the virus is released into the cytoplasm (d). Possible antiviral targets are shown with examples of compounds inhibiting the step.