Increased Sialylation of Anti-Thomsen-Friedenreich Antigen (CD176) Antibodies in Patients with Gastric Cancer: A Diagnostic and Prognostic Potential

Table 2

The sensitivity, specificity, and accuracy of diagnostics (ACC) for the main parameters under study.

	Sensitivity (95% CI)	Specificity (95% CI)	ROC curve area (95% CI)	Value	ACC
Anti-TF IgA	0.68 (0.51–0.82)	0.77 (0.56–0.91)	0.70 (0.57–0.83)	0.007	0.719
Anti-TF IgG	0.55 (0.44–0.67)	0.58 (0.41–0.74)	0.53 (80.42–0.65)	0.543	0.563
Anti-TF IgM	0.66 (0.57–0.75)	0.69 (0.56–0.81)	0.69 (0.61–0.77)	<0.0001	0.670
SNA	0.60 (0.51–0.69)	0.62 (0.49–0.74)	0.66 (80.58–0.7)	0.000	0.611
SNA/anti-TF IgA	0.71 (0.54–0.85)	0.73 (0.52–0.88)	0.79 (0.67–0.91)	<0.0001	0.719
SNA/anti-TF IgG	0.66 (0.54–0.77)	0.60 (0.43–0.76)	0.64 (0.53–0.75)	0.017	0.643
SNA/anti-TF IgM	0.70 (0.61–0.78)	0.67 (0.54–0.79)	0.73 (0.66–0.80)	<0.0001	0.692

95% CI: 95% confidence interval (in brackets).
ACC: accuracy of diagnostics for each subgroup calculated by the ROC analysis as compared with that of the corresponding subgroup of controls (31 blood donors and 30 patients with nonmalignant gastric diseases). ACC = (TP + TN)/(TP + TN + FP + FN) where TP: true positive cases, TN: true negative cases, FP: false positive cases, and FN: false negative cases.