Biology of Ageing and Role of Dietary Antioxidants

Table 1

Selected longevity determined genes recently recognized in fruit flies, for which allelic variation is associated with extension in longevity.

Gene names	Molecular mechanism
Mth	A P-element insertion at Mth increases lifespan by 35% [31]
Indy	P-element insertion at Indy shows extended mean lifespan [35]
Chico	Heterozygous for chico shows an increase in median lifespan [36]
dTOR	Inhibition of TOR pathway leads to 24–26% lifespan extension [37]
Sirtuins	Gene upregulation of sirtuins increases the lifespan [38]