Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure

Table 4

Top 10 diseases overrepresented by the differentially expressed genes under the exposure of varying doses of  ⁶⁰Co exposure in human PBMC.

0.5 Gy	1 Gy	2.5 Gy	5 Gy
Glioma	HIV	Necrosis	Neuroblastoma
Carcinoma, small cell	Leukemia	Hernia	Hernia
Neoplasms	Viral diseases	Viral diseases	Hematologic
Cancer or viral infections	Cancer or viral infections	HIV	Peripheral
Carcinoma, hepatocellular	Shock	Immunologic deficiency syndromes	Necrosis
Liver neoplasms	Immunologic deficiency syndromes	Chorioamnionitis	Therapy-related acute myeloid leukemia (t-ML)
Carcinoma	Death	Retroviridae infections	Connective tissue diseases
Hypercortisolism	Sexually transmitted diseases	Preterm rupture of membranes	Autoimmune diseases
Glioblastoma	Lentivirus infections	Lentivirus infections	Disease susceptibility
Immune system diseases	Retroviridae infections	Periodontitis	Genetic predisposition to disease

All disease associations were filtered by BH-adjusted value <0.05.