In Vitro Antiplasmodial Activities and Synergistic Combinations of Differential Solvent Extracts of the Polyherbal Product, Nefang

Table 6

In vitro antiplasmodial activity (EC₅₀) of paired extracts exhibiting antagonistic interaction (CI > 1.5) at equipotency ratios.

Number	Extract combination	EC50 ratio (µg/mL)	EC50 ratio in combination (µg/mL)	FIC50 A	FIC50 B	Fold increase	Combination index (CI)
1	MiB/Pg-EtOH	14/23	16.77/27.55	1.20	1.20	0.83/0.83	2.40
2	MiB/Cc-EtOH	14/54.84	24.85/97.33	1.78	1.78	0.56/0.56	3.56
3	MiB/Cs-EtOH	14/86.08	10.86/66.79	0.78	0.78	1.29/1.29	1.56
4	MiL/Cp-EtOH	16.34/121.60	12.33/91.78	0.75	0.75	1.33/1.33	1.50
5	Pg/Cc-EtOH	23/54.84	24.47/58.34	1.06	1.06	0.94/0.94	2.12

Results presented as mean, 𝑛=3.
EtOH: ethanol; Aq: aqueous.