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BioMed Research International
Volume 2014, Article ID 841798, 13 pages
http://dx.doi.org/10.1155/2014/841798
Review Article

Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba

1School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK
2Department of Neuroscience and Imaging, University “G. d’Annunzio”, 66100 Chieti, Italy
3Cranfield University, Bedfordshire MK43 0AL, UK

Received 24 February 2014; Revised 23 May 2014; Accepted 26 May 2014; Published 15 June 2014

Academic Editor: Zsolt Demetrovics

Copyright © 2014 Ornella Corazza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. A. Pratap and S. Rajender, “Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities,” Frontiers in Bioscience, vol. 4, pp. 167–180, 2012. View at Google Scholar · View at Scopus
  2. N. Campbell, J. P. Clark, V. J. Stecher et al., “Adulteration of purported herbal and natural sexual performance enhancement dietary supplements with synthetic phosphodiesterase type 5 inhibitors,” Journal of Sexual Medicine, vol. 10, no. 7, pp. 1842–1849, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S. L. Kenyon, J. Button, P. Perella, D. A. McKeown, and D. W. Holt, “An herbal remedy for impotence: more than was bargained for,” Journal of Clinical Pharmacology, vol. 46, no. 11, pp. 1379–1381, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. B. J. Venhuis, M. E. Zwaagstra, J. D. J. van den Berg et al., Illicit Erectile Dysfunction Products in the Netherlands. A Decade of Trends and a 2007–2010 Product Update, National Institute for Public Health and the Environment, 2011.
  5. M. Evans-Brown, J. McVeigh, C. Perkins, and M. A. Bellis, Human Enhancement Drugs: The Emerging Challenges to Public Health, North West Public Health Observatory, 2012.
  6. S. Balayssac, V. Gilard, C. Zedde, R. Martino, and M. Malet-Martino, “Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants,” Journal of Pharmaceutical and Biomedical Analysis, vol. 63, pp. 135–150, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Shamloul, “Natural aphrodisiacs,” Journal of Sexual Medicine, vol. 7, no. 1, pp. 39–49, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Ernst, “Harmless herbs? A review of the recent literature,” The American Journal of Medicine, vol. 104, no. 2, pp. 170–178, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Bent and R. Ko, “Commonly used herbal medicines in the United States: a review,” The American Journal of Medicine, vol. 116, no. 7, pp. 478–485, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. Adverse event reporting for dietary supplements: An inadequate safety valve. OEI-01-00-00180. Office of the Inspector General, HHS, 2001. 2001.
  11. P. G. Shekelle, M. L. Hardy, S. C. Morton et al., “Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis,” Journal of the American Medical Association, vol. 289, no. 12, pp. 1537–1545, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Keller, M. Blench, H. Tolentino et al., “Use of unstructured event-based reports for global infectious disease surveillance,” Emerging Infectious Diseases, vol. 15, no. 5, pp. 689–695, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Blaschek, S. Ebel, E. Hackenthal et al., Hagers Handbuch der Drogen und Arzneistoffe, Springer, Heidelberg, Germany, 2007.
  14. J. M. Betz, K. D. White, and A. H. der Marderosian, “Gas chromatographic determination of yohimbine in commercial yohimbe products,” Journal of AOAC International, vol. 78, no. 5, pp. 1189–1194, 1995. View at Google Scholar · View at Scopus
  15. GPHIN, Syntrax contains the female qualm of sexual impotence medicine weight loss looking at acute disease, Communication from Hong Kong, 2009.
  16. GPHIN, Again feel the woman! Communication posted on 2012/05/15 from Russia, 2012.
  17. GPHIN, FDA warns on sex, diet pills, communication posted on 2012/03/07 from South Florida Sun-Sentine, United States, 2012.
  18. GPHIN, Open once strong medicine contains hazardous wastes. The bureau appeals to sanitary science to stop use, Singapore, 2010.
  19. M. R. Goldberg and D. Robertson, “Yohimbine: a pharmacological probe for study of the α2-adrenoreceptor,” Pharmacological Reviews, vol. 35, no. 3, pp. 143–180, 1983. View at Google Scholar · View at Scopus
  20. A. Y. W. Chang, C.-M. Huang, J. Y. H. Chan, and S. H. H. Chan, “Involvement of noradrenergic innervation from locus coeruleus to hippocampal formation in negative feedback regulation of penile erection in the rat,” Hippocampus, vol. 11, no. 6, pp. 783–792, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Porst, A. Burnett, G. Brock et al., “SOP conservative (Medical and Mechanical) treatment of erectile dysfunction,” Journal of Sexual Medicine, vol. 10, no. 1, pp. 130–171, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. U. Simonsen, D. Prieto, M. Hernández, I. Sáenz De Tejada, and A. García-Sacristán, “Prejunctional α2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries,” Journal of Urology, vol. 157, no. 6, pp. 2356–2360, 1997. View at Google Scholar · View at Scopus
  23. J. A. Owen, S. L. Nakatsu, J. Fenemore, M. Condra, D. H. C. Surridge, and A. Morales, “The pharmacokinetics of yohimbine in man,” European Journal of Clinical Pharmacology, vol. 32, no. 6, pp. 577–582, 1987. View at Publisher · View at Google Scholar · View at Scopus
  24. S. W. Tam, M. Worcel, and M. Wyllie, “Yohimbine: a clinical review,” Pharmacology and Therapeutics, vol. 91, no. 3, pp. 215–243, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. S. K. Guthrie, M. Hariharan, and L. J. Grunhaus, “Yohimbine bioavailability in humans,” European Journal of Clinical Pharmacology, vol. 39, no. 4, pp. 409–411, 1990. View at Google Scholar · View at Scopus
  26. Federal Institute for Risk Assessment, 2013, http://ec.europa.eu/food/food/labellingnutrition/vitamins/sa_yohimbe_en.pdf.
  27. E. Ernst and M. H. Pittler, “Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials,” Journal of Urology, vol. 159, no. 2, pp. 433–436, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. A. A. Adeniyi, G. S. Brindley, J. P. Pryor, and D. J. Ralph, “Yohimbine in the treatment of orgasmic dysfunction,” Asian Journal of Andrology, vol. 9, no. 3, pp. 403–407, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. D. K. Montague, J. P. Jarow, G. A. Broderick et al., “Chapter 1: the management of erectile dysfunction: an AUA update,” The Journal of Urology, vol. 174, no. 1, pp. 230–239, 2005. View at Google Scholar · View at Scopus
  30. GPHIN, Public urged not to buy or use slimming products with undeclared and banned drug ingredients, communication posted on 2013/06/05 from Hong Kong Government, 2013.
  31. B. Sandler and P. Aronson, “Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome,” Urology, vol. 41, no. 4, pp. 343–345, 1993. View at Google Scholar · View at Scopus
  32. A. Myers and F. Barrueto Jr., “Refractory priapism associated with ingestion of yohimbe extract,” Journal of Medical Toxicology, vol. 5, no. 4, pp. 223–225, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Kearney, N. Tu, and C. Haller, “Adverse drug events associated with yohimbine-containing products: a retrospective review of the California poison control system reported cases,” Annals of Pharmacotherapy, vol. 44, no. 6, pp. 1022–1029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. “National Center for Complementary and Alternative Medicine. Herbs at a glance: Yohimbe. [Internet],” 2007, http://nccam.nih.gov/health/yohimbe.
  35. GPHIN, Warning on of the use of sexual stimulants that contains a poisonous substance, communication posted on 2008/07/29 from Jordan (in Arabic), 2008.
  36. C. H. Linden, W. P. Vellman, and B. Rumack, “Yohimbine: a new street drug,” Annals of Emergency Medicine, vol. 14, no. 10, pp. 1002–1004, 1985. View at Google Scholar · View at Scopus
  37. A. Giampreti, D. Lonati, C. Locatelli, L. Rocchi, and M. T. Campailla, “Acute neurotoxicity after yohimbine ingestion by a body builder,” Clinical Toxicology, vol. 47, no. 8, pp. 827–829, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. G. F. Gonzales, “Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the peruvian highlands,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 193496, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Clément, D. A. Diazgrados, B. Avula et al., “Influence of colour type and previous cultivation on secondary metabolites in hypocotyls and leaves of maca (Lepidium meyenii Walpers),” Journal of the Science of Food and Agriculture, vol. 90, no. 5, pp. 861–869, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. B. L. Zheng, K. He, C. H. Kim et al., “Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats,” Urology, vol. 55, no. 4, pp. 598–602, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. A. F. G. Cicero, E. Bandieri, and R. Arletti, “Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity,” Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 225–229, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. A. F. G. Cicero, S. Piacente, A. Plaza, E. Sala, R. Arletti, and C. Pizza, “Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts,” Andrologia, vol. 34, no. 3, pp. 177–179, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Lentz, K. Gravitt, C. C. Carson, L. Marson, and F. Giuliano, “Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior,” Journal of Sexual Medicine, vol. 4, no. 2, pp. 332–340, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. B.-C. Shin, M. S. Lee, E. J. Yang, H.-S. Lim, and E. Ernst, “Maca (L. meyenii) for improving sexual function: a systematic review,” BMC Complementary and Alternative Medicine, vol. 10, article 44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. N. A. Brooks, G. Wilcox, K. Z. Walker, J. F. Ashton, M. B. Cox, and L. Stojanovska, “Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content,” Menopause, vol. 15, no. 6, pp. 1157–1162, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. G. F. Gonzales, A. Córdova, K. Vega et al., “Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men,” Andrologia, vol. 34, no. 6, pp. 367–372, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Stone, A. Ibarra, M. Roller, A. Zangara, and E. Stevenson, “A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen,” Journal of Ethnopharmacology, vol. 126, no. 3, pp. 574–576, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. T. Zenico, A. F. G. Cicero, L. Valmorri, M. Mercuriali, and E. Bercovich, “Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial,” Andrologia, vol. 41, no. 2, pp. 95–99, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. M. S. Lee, B.-C. Shin, E. J. Yang, H.-J. Lim, and E. Ernst, “Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review,” Maturitas, vol. 70, no. 3, pp. 227–233, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. E. Ernst, P. Posadzki, and M. S. Lee, “Complementary and alternative medicine (CAM) for sexual dysfunction and erectile dysfunction in older men and women: an overview of systematic reviews,” Maturitas, vol. 70, no. 1, pp. 37–41, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Piacente, V. Carbone, A. Plaza, A. Zampelli, and C. Pizza, “Investigation of the tuber constituents of maca (Lepidium meyenii Walp.),” Journal of Agricultural and Food Chemistry, vol. 50, no. 20, pp. 5621–5625, 2002. View at Publisher · View at Google Scholar · View at Scopus
  52. APSSA, “From the French Agency of Sanitary Security on foods relative to the risk assessment for health by consuming pulverized maca roots or as alimentary supplement,” Afssa-Saisine 2004-SA-0155, 2004. View at Google Scholar
  53. G. F. Gonzales and C. Gonzales-Castañeda, “The methyltetrahydro-β-carbolines in Maca (Lepidium meyenii),” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 3, pp. 315–316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. Horny Goats Weed [Internet] 2013, http://www.herbwisdom.com/herb-horny-goats-weed.html.
  55. J. J. Liu, S. P. Li, and Y. T. Wang, “Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design,” Journal of Chromatography A, vol. 1103, no. 2, pp. 344–349, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. A. W. Shindel, Z.-C. Xin, G. Lin et al., “Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo,” Journal of Sexual Medicine, vol. 7, no. 4, pp. 1518–1528, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. Z.-C. Xin, E. K. Kim, C. S. Lin et al., “Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities,” Asian Journal of Andrology, vol. 5, no. 1, pp. 15–18, 2003. View at Google Scholar · View at Scopus
  58. Z. Jiang, B. Hu, J. Wang et al., “Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum,” Journal of Huazhong University of Science and Technology, vol. 26, no. 4, pp. 460–462, 2006. View at Google Scholar · View at Scopus
  59. H. Ning, Z.-C. Xin, G. Lin, L. Banie, T. F. Lue, and C.-S. Lin, “Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells,” Urology, vol. 68, no. 6, pp. 1350–1354, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Zhang, A.-M. Li, B.-X. Liu et al., “Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway,” Asian Journal of Andrology, vol. 15, no. 1, pp. 143–148, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. Z.-B. Zhang and Q.-T. Yang, “The testosterone mimetic properties of icariin,” Asian Journal of Andrology, vol. 8, no. 5, pp. 601–605, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. B. Liu, H. Zhang, C. Xu et al., “Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons,” Brain Research, vol. 1375, pp. 59–67, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. C. Shao-Rui, X. Xiang-Zhen, W. Yu-Hua et al., “Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κb pathways,” Biological and Pharmaceutical Bulletin, vol. 33, no. 8, pp. 1307–1313, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. R. Feng, L. Feng, Z. Yuan et al., “Icariin protects against glucocorticoid-induced osteoporosis in vitro and prevents glucocorticoid-induced osteocyte apoptosis in vivo,” Cell Biochemistry and Biophysics, vol. 67, no. 1, pp. 189–197, 2013. View at Publisher · View at Google Scholar · View at Scopus
  65. L. Ye, J. Chen, and S. Liu, “Pharmacokinetics of icariin in rats,” Chinese Pharmaceutical Journal, vol. 34, no. 1, pp. 33–36, 1999. View at Google Scholar · View at Scopus
  66. W. Yang, X. C. Yu, X. Y. Chen, L. Zhang, C. T. Lu, and Y. Z. Zhao, “Pharmacokinetics and tissue distribution profile of icariin propylene glycol-liposome intraperitoneal injection in mice,” Journal of Pharmacology and Pharmacotherapeutics, vol. 64, no. 2, pp. 190–198, 2012. View at Publisher · View at Google Scholar
  67. M. N. Makarova, O. N. Pozharitskaya, A. N. Shikov, S. V. Tesakova, V. G. Makarov, and V. P. Tikhonov, “Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats,” Journal of Ethnopharmacology, vol. 114, no. 3, pp. 412–416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. T. Liu, H. Xin, W.-R. Li et al., “Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats,” Journal of Sexual Medicine, vol. 8, no. 10, pp. 2761–2772, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. W.-J. Liu, Z.-C. Xin, H. Xin, Y.-M. Yuan, L. Tian, and Y.-L. Guo, “Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats,” Asian Journal of Andrology, vol. 7, no. 4, pp. 381–388, 2005. View at Publisher · View at Google Scholar · View at Scopus
  70. J. F. Partin and Y. R. Pushkin, “Tachyarrhythmia and hypomania with horny goat weed,” Psychosomatics, vol. 45, no. 6, pp. 536–537, 2004. View at Publisher · View at Google Scholar · View at Scopus
  71. D. Metz, P. Weston, and D. Barker, “Case report of vasculitic rash induced by Ginkgo biloba and/or Horny Goat Weed,” BMJ Case Reports, vol. 2009, Article ID bcr07.2008.0399, 2009. View at Publisher · View at Google Scholar
  72. C. J. Fehske, K. Leuner, and W. E. Müller, “Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment,” Pharmacological Research, vol. 60, no. 1, pp. 68–73, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. K. R. Laws, H. Sweetnam, and T. K. Kondel, “Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta-analysis,” Human Psychopharmacology, vol. 27, no. 6, pp. 527–533, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. C. A. Schmitt and V. M. Dirsch, “Modulation of endothelial nitric oxide by plant-derived products,” Nitric Oxide—Biology and Chemistry, vol. 21, no. 2, pp. 77–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  75. C. Ude, M. Schubert-Zsilavecz, and M. Wurglics, “Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients,” Clinical Pharmacokinetics, vol. 52, no. 9, pp. 727–749, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. D. MacKay, “Nutrients and botanicals for erectile dysfunction: examining the evidence,” Alternative Medicine Review, vol. 9, no. 1, pp. 4–16, 2004. View at Google Scholar · View at Scopus
  77. B.-J. Kang, S.-J. Lee, M.-D. Kim, and M.-J. Cho, “A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction,” Human Psychopharmacology, vol. 17, no. 6, pp. 279–284, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. D. Wheatley, “Triple-blind, placebo-controlled trial of Gingko biloba in sexual dysfunction due to antidepressant drugs,” Human Psychopharmacology, vol. 19, no. 8, pp. 545–548, 2004. View at Publisher · View at Google Scholar · View at Scopus
  79. R. Mazaro-Costa, M. L. Andersen, H. Hachul, and S. Tufik, “Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women?” Journal of Sexual Medicine, vol. 7, no. 11, pp. 3695–3714, 2010. View at Publisher · View at Google Scholar · View at Scopus
  80. National Institutes of Health, “Ntp technical report on the toxicology and carcinogenesis studies of Ginkgo biloba extract (cas no. 90045-36-6)in f344/n rats and b6c3f1/n mice(gavage studies),” 184 p. NIH Publication No. 13-5920, 2013.
  81. A. A. Hardigree and J. L. Epler, “Comparative mutagenesis of plant flavonoids in microbial systems,” Mutation Research, vol. 58, no. 2-3, pp. 231–239, 1978. View at Google Scholar · View at Scopus
  82. J. Birks, E. V. Grimley, and M. Van Dongen, “Ginkgo biloba for cognitive impairment and dementia,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD003120, 2002. View at Google Scholar · View at Scopus
  83. A. Fugh-Berman, “Herb-drug interactions,” The Lancet, vol. 355, no. 9198, pp. 134–138, 2000. View at Google Scholar · View at Scopus
  84. S. Bent, H. Goldberg, A. Padula, and A. L. Avins, “Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature,” Journal of General Internal Medicine, vol. 20, no. 7, pp. 657–661, 2005. View at Publisher · View at Google Scholar · View at Scopus
  85. E. Leistner and C. Drewke, “Ginkgo biloba and ginkgotoxin,” Journal of Natural Products, vol. 73, no. 1, pp. 86–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. National Institutes of Health, “MedlinePlus Herbs and Supplements: Ginkgo (Ginkgo biloba L.) [Internet],” 2013, http://www.nlm.nih.gov/medlineplus/druginfo/natural/333.html.
  87. B. E. Rollin, “An ethicist's commentary on animal welfare versus food safety in collecting antler velvet,” Canadian Veterinary Journal, vol. 42, no. 5, pp. 330–331, 2001. View at Google Scholar · View at Scopus
  88. E. S. Williams, “Chronic wasting disease,” Veterinary Pathology, vol. 42, no. 5, pp. 530–549, 2005. View at Publisher · View at Google Scholar · View at Scopus
  89. R. C. Angers, T. S. Seward, D. Napier et al., “Chronic wasting disease prions in eik antler velvet,” Emerging Infectious Diseases, vol. 15, no. 5, pp. 696–703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  90. S. E. Saunders, S. L. Bartelt-Hunt, and J. C. Bartz, “Occurrence, transmission, and zoonotic potential of chronic wasting disease,” Emerging Infectious Diseases, vol. 18, no. 3, pp. 369–376, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. S. Kumar, R. Madaan, and A. Sharma, “Pharmacological evaluation of bioactive principle of Turnera aphrodisiaca,” Indian Journal of Pharmaceutical Sciences, vol. 70, no. 6, pp. 740–744, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. R. Arletti, A. Benelli, E. Cavazzuti, G. Scarpetta, and A. Bertolini, “Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats,” Psychopharmacology, vol. 143, no. 1, pp. 15–19, 1999. View at Publisher · View at Google Scholar · View at Scopus
  93. GPHIN, Kazakhstan has forbidden import of smoking grassy mixes, communication posted on 2010/01/21 from Kazakhstan (in Russian), 2010.
  94. O. Corazza, S. Assi, P. Simonato et al., “Promoting innovation and excellence to face the rapid diffusion of novel Psychoactive substances in the EU: the outcomes of the reDNet project,” Human Psychopharmacology, vol. 28, no. 4, pp. 317–323, 2013. View at Publisher · View at Google Scholar · View at Scopus
  95. F. Schifano, A. Ricciardi, O. Corazza et al., “New drugs and role of the web: psychonaut Web Mapping Project,” Rivista di Psichiatria, vol. 45, no. 2, pp. 88–93, 2010. View at Publisher · View at Google Scholar · View at Scopus
  96. V. Auwärter, S. Dresen, W. Weinmann, M. Müller, M. Pütz, and N. Ferreirós, ““Spice” and other herbal blends: harmless incense or cannabinoid designer drugs?” Journal of Mass Spectrometry, vol. 44, no. 5, pp. 832–837, 2009. View at Publisher · View at Google Scholar
  97. C. R. Ossian, “The Most Beautiful of Flowers (review of Water Lilies and Lotuses in ancient Egypt),” KMT Magazine, vol. 1, pp. 48–59, 1999. View at Google Scholar
  98. W. A. Emboden, “Transcultural use of narcotic water lilies in ancient Egyptian and Maya drug ritual,” Journal of Ethnopharmacology, vol. 3, no. 1, pp. 39–83, 1981. View at Google Scholar · View at Scopus
  99. J. Waynberg, “Yohimbine vs. muira puama in the treatment of sexual dysfunction,” The American Journal of Natural Medicine, vol. 1, pp. 8–9, 1994. View at Google Scholar
  100. J. Waynberg and S. Brewer, “Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women,” Advances in Therapy, vol. 17, no. 5, pp. 255–262, 2000. View at Google Scholar · View at Scopus
  101. C. M. Meston and J. R. Heiman, “Ephedrine-activated physiological sexual arousal in women,” Archives of General Psychiatry, vol. 55, no. 7, pp. 652–656, 1998. View at Publisher · View at Google Scholar · View at Scopus
  102. M. Scibona, P. Meschini, S. Capparelli, C. Pecori, P. Rossi, and G. F. Menchini Fabris, “L-arginine and male infertility,” Minerva Urologica e Nefrologica, vol. 46, no. 4, pp. 251–253, 1994. View at Google Scholar · View at Scopus
  103. “European monitoring centre for drugs and drug addictions,” Annual Report on the State of the Drugs Problem in Europe, Lisbon, Portugal, 2012.
  104. GPHIN, Health food is contained forbidding medicine changing a name sell again and again, communication posted on 2010/07/28 from Taiwan, 2010.
  105. GPHIN, Nationwide Track and Trace System Urgently Needed, communication posted on 2013/07/01 from United States, 2013.
  106. F. Schifano, P. Deluca, L. Agosti, G. Martinotti, J. M. Corkery, B. Alex et al., “Psychonaut 2002 Research Group. New trends in the cyber and street market of recreational drugs? The case of 2C-T-7 (“Blue Mystic”),” Journal of Psychopharmacology, vol. 19, no. 6, pp. 675–679, 2005. View at Google Scholar
  107. I. Sáenz de Tejada, J. Angulo, S. Cellek et al., “Pathophysiology of erectile dysfunction,” Journal of Sexual Medicine, vol. 2, no. 1, pp. 26–39, 2005. View at Publisher · View at Google Scholar · View at Scopus