Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Figure 3

Effects of Lipopolysaccharide, green tea, piceatannol, Markhamia platycalyx, and Schotia brachypetala leaves and Schotia brachypetala stalk on the mean discrimination ratio using object recognition test. Normal group animals were injected with DMSO or saline 0.9% i.p. once with nonsignificant results between them. The 6 other groups had Alzheimer’s disease that was induced by i.p. injection of LPS once. Five of these groups were treated with either PCT (2.5 mg/kg) or 100 mg/kg of GT, MP, SBS, or SBL daily for 6 days. The animals of each group (𝑛 = 8–10) were subjected to object recognition testing on the 7th day testing and exploration attempts towards each object within 4 minutes were recorded for each mouse. Then the discrimination ratio was calculated for each mouse. Statistical analysis was performed using unpaired 𝑡-test to compare every two groups. Each value represents mean ± standard error of mean. ∗Significantly different from normal at 𝑃<0.05. ∗∗Significantly different from normal at 𝑃<0.01. ∗∗∗Significantly different from normal at 𝑃<0.001. +Significantly different from LPS at 𝑃<0.05. ++Significantly different from LPS at 𝑃<0.01. +++Significantly different from LPS at 𝑃<0.001. MDR: mean discrimination ratio. DMSO: dimethyl sulfoxide. LPS: Lipopolysaccharide. GT: green tea extract of Camellia sinensis. PCT: piceatannol. SBS: Schotia brachypetala leaves. SBL: Schotia brachypetala stalk. MP: Markhamia platycalyx. i.p. intraperitoneal injection.