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BioMed Research International
Volume 2014 (2014), Article ID 847132, 6 pages
Research Article

The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study

1School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
2Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110052, India

Received 26 February 2014; Accepted 6 May 2014; Published 9 July 2014

Academic Editor: Abhay R. Satoskar

Copyright © 2014 Anil Kumar Verma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele “G” (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR, ) and homozygous mutant (QQ versus RR, ) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).