Effects of SCH-23390 in Combination with a Low Dose of 17β-Estradiol on Anxiety-Like Behavior in Ovariectomized Rats

Figure 3

Effects of SKF-38393 (0.1 mg/kg, i.p.) and SCH-23390 (0.1 mg/kg, i.p.) on the behavior in OVX rats and OVX rats treated with low dose of 17β-E₂ (5.0 μg/rat, s.c.) in the open field test for 5 min. Columns represent the behavioral parameters as mean ± SEM. Light columns represent crossing, grey columns represent rearing, and dark columns represent grooming. Each group was comprised of 10 rats. *𝑃<0.05 versus control intact rats (control 1); **𝑃<0.05 versus control OVX rats (control 2); ^#𝑃<0.05 versus OVX rats treated with 17β-E₂.