An In Vivo Microdialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats
Figure 5
Brain dialysate : blood dialysate FLZ AUC ratios for each treatment group. There was a 3-fold increase in the brain dialysate : blood dialysate FLZ AUC ratio in the FLZ + ZOSUQ-N group relative to that in the FLZ only-N group () and a 4-fold increase in the FLZ + ZOSUQ-PD group relative to that in the FLZ only-PD group (). The 20% reduction observed in the FLZ only-PD group relative to the FLZ only-N group was not statistically significant (). The mean ratios in the FLZ + ZOSUQ-N and FLZ + ZOSUQ-PD groups were not significantly different (). Data are expressed as the means ± SD ( per group).
