Serial Changes of Neointimal Tissue after Everolimus-Eluting Stent Implantation in Porcine Coronary Artery: An Optical Coherence Tomography Analysis

Table 1

Quantitative coronary angiographic and optical coherence tomographic findings of the entire stent segment at 1, 3, and 6 months after stent implantation.

	Bare-metal stent ()			Everolimus-eluting stent ()
	1 month	3 months	6 months	1 month	3 months	6 months
Quantitative coronary angiography analyses
Proximal reference, mm	2.7 (2.6–3.1)	2.8 (2.6–3.2)	2.8 (2.5–3.2)	2.9 (2.7–3.2)	3.0 (2.6–3.1)	2.7 (2.4–3.1)
Distal reference, mm	2.6 (2.4–2.8)	2.6 (2.3–3.0)	2.5 (2.2–2.9)	2.6 (2.4–2.8)	2.5 (2.4–2.7)	2.5 (2.3–2.7)
Minimal lumen diameter, mm	2.2 (2.0–2.5)	2.2 (2.1–2.4)	2.2 (2.0–2.4)	2.4 (2.0–2.6)*	1.7 (1.4–2.3)	1.8 (1.5–2.2)
Optical coherence tomography findings
Neointimal thickness, m	190.4 (127.0–243.9)	182.2 (131.9–229.4)	169.8 (112.7–211.1)	120.6 (93.8–203.9)*	276.5 (172.2–428.1)	269.6 (199.9–396.4)
Stent area, mm^2	6.1 (5.2–6.8)	6.1 (5.4–7.0)	6.0 (5.2–6.8)	6.2 (5.3–6.9)	6.3 (5.4–7.0)	6.3 (5.0–6.9)
Lumen area, mm^2	4.5 (3.8–5.6)	4.7 (4.0–5.4)	4.6 (3.8–5.3)	4.9 (4.1–5.8)*	3.8 (3.0–4.9)	3.8 (3.2–4.5)
Neointimal area, mm^2	1.6 (1.1–1.9)	1.4 (1.0–1.9)	1.4 (0.9–1.7)	1.3 (0.9–1.7)*	2.5 (1.4–3.6)	2.4 (1.6–3.1)
Percentage of neointimal hyperplasia area, %	25.3 (19.2–29.4)	23.9 (17.3–32.0)	23.2 (13.1–29.9)	21.5 (12.9–28.1)*	39.1 (24.1–53.7)	35.4 (31.7–45.0)

, using Friedman tests.