Moderate Intra-Abdominal Hypertension Leads to Anaerobic Metabolism in the Rectus Abdominis Muscle Tissue of Critically Ill Patients: A Prospective Observational Study
Table 1
Patients’ clinical characteristics at the baseline (at enrolment to study) and during the study period. Data are presented as median (interquartile range). compared to baseline.
Baseline
12–24 hours
24–48 hours
48–72 hours
IAP, (mmHg)
14.5 (12.5–17.8)
12.9 (10.4–14.3)*
11 (9.3–13.9)*
9.8 (9.3–14.9)*
MAP, (mmHg)
83 (75–89)
91 (82–95)
89 (80–96)
89 (87–919)
APP, (mmHg)
70 (58–74)
76 (66–85)*
72 (70–819)
81 (77–87)*
Heart rate, (beats/min)
106 (94–121)
107 (93–116)
92 (89–106)
90 (86–97)*
CVP, (mmHg)
19 (16–21)
17 (12–22)
15 (12–18)
14 (12–19)
Arterial glucose, (mmol/L)
7.6 (5.4–9.7)
8.0 (6.0–8.7)*
7.5 (6.6–9.4)
7.1 (6.2–8.9)
Arterial lactate, (mmol/L)
1.9 (1.3–3.75)
1.9 (1.1–2.9)
1.9 (0.8–2.2)
1.5 (0.8–1.8)
Arterial pH
7.42 (7.34–7.47)
7.44 (7.39–7.48)
7.44 (7.38–7.47)
7.43 (7.40–7.46)
Arterial pCO2, (mmHg)
38.3 (32.2–46.6)
40.6 (37.3–45.59)
41.4 (38.4–48.0)
42.3 (40.8–45.8)
SOFA score
7 (6–9)
6 (5–9)
8 (4–10)
6 (3–7)
Noradrenaline dose, (g/kg/min)
0.22 (0.11–0.35)
0.32 (0.11–0.53)
0.12 (0.07–0.27)
0.09 (0.03–0.20)*
CVI
3.5 (0–4.3)
4 (0–4.5)
2 (0–4.5)
3 (0–3.5)
IAP: intra-abdominal pressure; MAP: mean arterial pressure; APP: abdominal perfusion pressure; CVP: central venous pressure; SOFA: Sequential Organ Failure Assessment score; CVI: cumulative vasopressor index (a method for quantifying total amount of vasopressor support at a given time point) [18].
