Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice
Oxidative stress after prolonged cerebral hypoperfusion in young groups. ((a)–(d)) Photomicrographs and the number of 8OHdG- ((a), (b)) and HHE- ((c), (d)) positive cells in the corpus callosum at day 28 after BCAS. Scale bars = 20 μm. ((e), (f)) Double immunofluorescence staining for 8OHdG (green), HHE (green), GSTπ (red), and merged images in the corpus callosum at day 28 after reperfusion. Scale bars = 20 μm. ((g), (h)) Western blotting (g) and densitometric analysis (h) of oxidized proteins. Data are mean ± SEM of five mice in each group. , , compared with the preoperation group (pre). , , compared with the same time points. Pre: preoperation.
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