TY - JOUR
A2 - Lu, Cheng-Hsien
AU - Lu, Kang
AU - Wang, Hao-Kuang
AU - Yeh, Chih-Ching
AU - Huang, Chih-Yuan
AU - Sung, Pi-Shan
AU - Wang, Liang-Chao
AU - Muo, Chih-Hsin
AU - Sung, Fung-Chang
AU - Chen, Han-Jung
AU - Li, Ying-Chun
AU - Chang, Li-Ching
AU - Tsai, Kuen-Jer
PY - 2014
DA - 2014/04/30
TI - Association between Autoimmune Rheumatic Diseases and the Risk of Dementia
SP - 861812
VL - 2014
AB - Aim. Autoimmune rheumatic diseases (ARD) are characterized by systemic inflammation and may affect multiple organs and cause vascular events such as ischemic stroke and acute myocardial infarction. However, the association between ARD and increased risk of dementia is uncertain. This is a retrospective cohort study to investigate and compare the risk of dementia between patients clinically diagnosed with ARD and non-ARD patients during a 5-year follow-up period. Methods. Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID2000). We included 1221 patients receiving ambulatory or hospitalization care and 6105 non-ARD patients; patients were matched by sex, age, and the year of index use of health care. Each patient was studied for 5 years to identify the subsequent manifestation of dementia. The data obtained were analyzed by Cox proportional hazard regression. Results. During the 5-year follow-up period, 30 ARD (2.48%) and 141 non-ARD patients (2.31%) developed dementia. During the 5-year follow-up period, there were no significant differences in the risks of any type of dementia (adjusted hazard ratio (HR), 1.18; 95% CI, 0.79–1.76) in the ARD group after adjusting for demographics and comorbidities. Conclusions. Within the 5-year period, patients with and without ARD were found to have similar risks of developing dementia.
SN - 2314-6133
UR - https://doi.org/10.1155/2014/861812
DO - 10.1155/2014/861812
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -