Association between Autoimmune Rheumatic Diseases and the Risk of Dementia
Table 3
Crude and adjusted hazard ratios by dementia subtype among sampled patients during the 5-year follow-up from index health care utilization.
Dementia
Comparison
All
RA
SLE
SS
Alzheimer’s disease
Yes (%)
9 (0.15)
0 (0.00)
0 (0.00)
0 (0.00)
0 (0.00)
Crude HR (95% CI)
1.00
Adjusted HR (95% CI)
1.00
Vascular dementia
Yes (%)
12 (0.20)
2 (0.16)
2 (0.31)
0 (0.00)
0 (0.00)
Crude HR (95% CI)
1.00
0.86 (0.19–3.82)
1.66 (0.37–7.42)
—
—
P value
0.43
0.51
Adjusted HR (95% CI)
1.00
0.99 (0.22–4.45)
1.52 (0.34–6.86)
—
—
P value
0.51
0.37
Unspecific dementia
Yes (%)
120 (1.97)
28 (2.29)
18 (2.83)
5 (1.67)
5 (2.89)
Crude HR (95% CI)
1.00
1.21 (0.80–1.82)
1.51 (0.92–2.47)
0.84 (0.34–2.05)
1.54 (0.63–3.78)
P value
0.57
0.33
0.68
0.41
Adjusted HR (95% CI)
1.00
1.28 (0.84–1.93)
1.27 (0.77–2.10)
3.48 (1.40–8.63)
0.91 (0.37–2.26)
P value
0.32
0.24
0.03
0.46
Hazard ratio was calculated using Cox proportional regression method during the 5-year follow-up period. Adjustments were made for demographic characteristics (age, sex, and the geographical region) and selected comorbidities in the patients (diabetes, hyperlipidemia, hypertension, stroke, heart failure, and atrial fibrillation).
