BioMed Research International

Research Article

Massive Exploration of Perturbed Conditions of the Blood Coagulation Cascade through GPU Parallelization

Table 1

Reaction-based model of the blood coagulation cascade (reduced version of the “Platelet-Plasma” model described in [30]). The model consists in 96 reactions among 71 molecular species. With the exception of reaction (see Section 3.1), the values of all reaction constants were taken from [30].
Reactants Products Constant ( )
TF + fVII TF-fVII  M−1 s−1
TF-fVII TF + fVII  s−1
TF + fVIIa TF-fVIIa  M−1 s−1
TF-fVIIa TF + fVIIa  s−1
TF-fVIIa + fVII TF-fVIIa + fVIIa  M−1 s−1
fXa + fVII fXa + fVIIa  M−1 s−1
fIIa + fVII fIIa + fVIIa  M−1 s−1
TF-fVIIa + fX TF-fVIIa-fX  M−1 s−1
TF-fVIIa-fX TF-fVIIa + fX  s−1
TF-fVIIa-fX TF-fVIIa-fXa 6.00 s−1
TF-fVIIa-fXa TF-fVIIa + fXa 19.00 s−1
TF-fVIIa + fXa TF-fVIIa-fXa  M−1 s−1
TF-fVIIa + fIX TF-fVIIa-fIX  M−1 s−1
TF-fVIIa-fIX TF-fVIIa + fIX 2.40 s−1
TF-fVIIa-fIX TF-fVIIa + fIXa 1.80 s−1
fII + fXa fIIa + fXa  M−1 s−1
fIIa + fVIII fIIa + fVIIIa  M−1 s−1
fVIIIa + fIXa fIXa-fVIIIa  M−1 s−1
fIXa-fVIIIa fVIIIa + fIXa  s−1
fIXa-fVIIIa + fX fIXa-fVIIIa-fX  M−1 s−1
fIXa-fVIIIa-fX fIXa-fVIIIa + fX  s−1
fIXa-fVIIIa-fX fIXa-fVIIIa + fXa 8.20 s−1
fVIIIa fVIIIa1-L + fVIIIa2  s−1
fVIIIa1-L + fVIIIa2 fVIIIa   M−1 s−1
fIXa-fVIIIa-fX fVIIIa1-L + fVIIIa2 + fX + fIXa  s−1
fIXa-fVIIIa fVIIIa1-L + fVIIIa2 + fIXa  s−1
fIIa + fV fIIa + fVa  M−1 s−1
fXa + fVa fXa-fVa  M−1 s−1
fXa-fVa fXa + fVa 0.2 s−1
fXa-fVa + fII fXa-fVa-fII  M−1 s−1
fXa-fVa-fII fXa-fVa + fII 103.00 s−1
fXa-fVa-fII fXa-fVa + fmIIa 63.50 s−1
fXa-fVa + fmIIa fXa-fVa + fIIa  M−1 s−1
fXa + TFPI fXa-TFPI  M−1 s−1
fXa-TFPI fXa + TFPI  s−1
TF-fVIIa-fXa + TFPI TF-fVIIa-fXa-TFPI   M−1 s−1
TF-fVIIa-fXa-TFPI TF-fVIIa-fXa + TFPI   s−1
TF-fVIIa + fXa-TFPI TF-fVIIa-fXa-TFPI  M−1 s−1
fXa + ATIII fXa-ATIII  M−1 s−1
fmIIa + ATIII fmIIa-ATIII  M−1 s−1
fIXa + ATIII fIXa-ATIII  M−1 s−1
fIIa + ATIII fIIa-ATIII  M−1 s−1
TF-fVIIa + ATIII TF-fVIIa-ATIII  M−1 s−1
fXII fXIIa  s−1
fXIIa + fXII fXIIa-fXII  M−1 s−1
fXIIa-fXII fXIIa + fXII 750.00 s−1
fXIIa-fXII fXIIa + fXIIa  s−1
fXIIa + PKal fXIIa-PKal  M−1 s−1
fXIIa-PKal fXIIa + PKal  s−1
fXIIa-PKal fXIIa + Kal 40.00 s−1
fXII + Kal fXII-Kal  M−1 s−1
fXII-Kal fXII + Kal 45.30 s−1
fXII-Kal fXIIa + Kal 5.70 s−1
PKal + Kal Kal + Kal  M−1 s−1
Kal  s−1
fXIIa + C1inh fXIIa-C1inh  M−1 s−1
fXIIa + ATIII fXIIa-ATIII 21.60 M−1 s−1
fXI + fIIa fXI-fIIa  M−1 s−1
fXI-fIIa fXI + fIIa 5.00 s−1
fXI-fIIa fXIa + fIIa  s−1
fXIIa + fXI fXIIa-fXI  M−1 s−1
fXIIa-fXI fXIIa + fXI 200 s−1
fXIIa-fXI fXIIa + fXIa  s−1
fXIa + fXI fXIa + fXIa  M−1 s−1
fXIa + ATIII fXIa-ATIII  M−1 s−1
fXIa + C1inh fXIa-C1inh  M−1 s−1
fXIa + A1AT fXIa-A1AT  M−1 s−1
fXIa + A2AP fXIa-A2AP  M−1 s−1
fXIa + fIX fXIa-fIX  M−1 s−1
fXIa-fIX fXIa + fIX 41.00 s−1
fXIa-fIX fXIa + fIXa 7.70 s−1
fIXa + fX fIXa-fX  M−1 s−1
fIXa-fX fIXa + fX 0.64 s−1
fIXa-fX fIXa + fXa  s−1
fXa + fVIII fXa-fVIII  M−1 s−1
fXa-fVIII fXa + fVIII 2.10 s−1
fXa-fVIII fXa + fVIIIa 0.023 s−1
fVIIa + fIX fVIIa-fIX  M−1 s−1
fVIIa-fIX fVIIa + fIX 0.90 s−1
fVIIa-fIX fVIIa + fIXa  s−1
fVIIa + fX fVIIa-fX  M−1 s−1
fVIIa-fX fVIIa + fX 210.00 s−1
fVIIa-fX fVIIa + fXa  s−1
Fbg + fIIa Fbg-fIIa  M−1 s−1
Fbg-fIIa Fbg + fIIa 636.00 s−1
Fbg-fIIa Fbn1 + fIIa + FPA 84.00 s−1
Fbn1 + fIIa Fbn1-fIIa  M−1 s−1
Fbn1-fIIa Fbn1 + fIIa 742.60 s−1
Fbn1-fIIa Fbn2 + fIIa + FPB 7.40 s−1
Fbn1 + Fbn1 (Fbn1)2  M−1 s−1
(Fbn1)2 2Fbn1  s−1
(Fbn1)2 + fIIa (Fbn1)2-fIIa  M−1 s−1
(Fbn1)2-fIIa (Fbn1)2 + fIIa 701.00 s−1
(Fbn1)2-fIIa (Fbn2)2 + fIIa + FPB 49.00 s−1
Fbn2 + fIIa Fbn2-fIIa  M−1 s−1
Fbn2-fIIa Fbn2 + fIIa  s−1