Lentivirus Mediated siRNA against GluN2B Subunit of NMDA Receptor Reduces Nociception in a Rat Model of Neuropathic Pain
Figure 5
Impact of Lv-siGluN2B on PWL and PWT in CCI rats. On the 1st, 3rd, 7th, 10th, 14th, 21st, 28th, and 35th days after intrathecal injection, CCI rats receiving intrathecal Lv-siGluN2B showed significantly attenuated thermal hyperalgesia (a) and mechanical allodynia (b) compared to CCI rats treated with Lv-GFP and NS, as showed by PWL ( versus NS and Lv-GFP groups, two-way ANOVO analysis followed by Turkey’s multiple comparisons, ) and PWT ( versus NS and Lv-GFP groups, two-way ANOVO analysis followed by Turkey’s multiple comparisons, ).
