Determinants of Disability in Multiple Sclerosis: An Immunological and MRI Study

Table 6

Univariate correlations between patients’ EDSS, MRI-derived, and immunological variables.

	SCC	95% CL		𝑃 value
MRI metrics
LV	0.420	0.151	0.612	0.001
NCV	−0.555	−0.709	−0.342	<0.0001
NGMV	−0.593	−0.736	−0.391	<0.0001
NWMV	0.095	−0.168	0.344	ns
NBV	−0.576	−0.724	−0.368	<0.0001
Left CST FA	−0.401	−0.595	−0.156	0.0016
Left CST MD	0.310	0.054	0.524	ns
Right CST FA	−0.469	−0.646	−0.236	0.0002
Right CST MD	0.365	0.114	0.567	0.0046
Cell percentages
CD4+IL17+	0.062	−0.210	0.324	ns
CD4+IFN𝛾+	−0.172	−0.480	0.179	ns
CD14+IL12p35+	0.054	−0.219	0.319	ns
CD14+IL6+	−0.418	−0.621	−0.153	0.0023
CD4+IL13+	−0.116	−0.386	0.175	ns
CD4+IL25+	−0.611	−0.760	−0.390	<0.0001
CD14+IL10+	0.095	−0.184	0.358	ns
CD14+TGF𝛽+	0.127	−0.155	0.388	ns
CD4+BDNF+	−0.057	−0.369	0.268	ns

Values are corrected for therapy (dichotomic variable), age and gender.
SCC: Spearman rank correlation coefficients; CL: confidence limits; LV: total brain lesion volume; NBV: normalized brain volume; NCV: normalized cortical grey matter volume; NGMV: normalized grey matter volume; WMV: normalized white matter volume; CST: corticospinal tract; MD: mean diffusivity; FA: fractional anisotropy. See the text for other abbreviations and statistical analysis details.