Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6

Table 4

Fluorescence intensity of c-Fos (arbitrary unit) in various regions of brain from normal and kindled mice.

Brain regions	Experimental group
	Normal control	PTZ-control	DZP + PTZ	HHL-6 + PTZ
Amygdala	12.23±2.9	38.17±5.08	14.94±1.99	15.21±2.3
Cortex	16.31±1.24	40.69±8.2	17.28±3.6	18.24±3.2
Hippocampus	15.29±2.3	44.27±7.43	20.09±3.77	16.92±2.75
Thalamus	12.58±1.79	45.36±3.70	18.33±2.19	15.58±3.74

Significant increase in the expression of c-Fos protein in the brain sections of control PTZ-kindled mice (𝑃<0.001) was centered especially in the hippocampal region followed by the thalamus. The HHL-6 treatment however reduces the expression of c-Fos in all four selected regions, that is, amygdala, cortex, hippocampus, and thalamus.