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BioMed Research International
Volume 2014 (2014), Article ID 878450, 14 pages
http://dx.doi.org/10.1155/2014/878450
Review Article

MicroRNAs: Promising New Antiangiogenic Targets in Cancer

1Molecular Oncology Laboratory, General University Hospital Research Fundation, Avda Tres Cruces 2, 46014 Valencia, Spain
2Department of Biotechnology, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
3Medical Oncology Department, General University Hospital, Avda Tres Cruces 2, 46014 Valencia, Spain
4Department of Medicine, Universitat de València, Avda Blasco Ibañez 15, 46010 Valencia, Spain

Received 6 June 2014; Accepted 18 July 2014; Published 14 August 2014

Academic Editor: Elisa Giovannetti

Copyright © 2014 Sandra Gallach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very numerous, have been phylogenetically conserved, and involved in biological processes such as development, differentiation, cell proliferation, and apoptosis. MicroRNAs contribute to modulating the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules and so they play a key role in both health and disease. Angiogenesis is the process of new blood vessel formation from preexisting ones, which is particularly relevant to cancer and its progression. Over the last few years, microRNAs have emerged as critical regulators of signalling pathways in multiple cell types including endothelial and perivascular cells. This review summarises the role of miRNAs in tumour angiogenesis and their potential implications as therapeutic targets in cancer.