7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome
Figure 2
T2 MRI mapping reflects inflammation and remodeling in experimental HisRS-induced myositis. Representative T2-weighted images of immunized mice ((a) upper panels) obtained before (time 0) and 14, 28, or 56 days after treatment reveal ongoing inflammatory involvement and are well compatible with results obtained at the same time points by histopathology in selected animals ((a) lower panels, H&E). Yellow arrows indicate the fibula (upper) and tibia (lower) bones, while red arrows show skeletal muscles (GS left and TA right). The graphs show the dynamic trends of T2-rt ((b) y-axis) and F.A. ((d) y-axis) in the longitudinal study of immunized and sham-treated mice before and at various times after treatment (x-axis, days). ; statistically different from sham-treated mice; . The graph in (c) depicts correlation analysis between T2-rt and the histological score that reflects muscle damage and infiltration (see Methods). for each time point. The time points considered for the correlation analysis were days 0, 14, 28, 42, and 56.
