Phytochemicals: A Multitargeted Approach to Gynecologic Cancer Therapy
Figure 2
Effects of piceatannol and CDDP treatment on tumor growth in a mouse model of OVCA. (a) Effect of CDDP (1.8 mg/kg, once per week) and piceatannol (20 mg/kg, 5 times per week) on tumor volume. Tumors were formed by subcutaneous insertion of OV2008 cells embedded in matrigel into the hind flanks of athymic nude mice. Tumors were measured over 18 days for the intervals indicated and volume was calculated using the equation . (b) Measurements of tumor weight on the day of sacrifice (). (c) Effect of CDDP and piceatannol treatment on mitochondrial morphology in recovered tumors. Taken from Farrand et al. [42].
