Research Article
Variations in KIR Genes: A Study in HIV-1 Serodiscordant Couples
Table 2
Activating/inhibitory KIR gene repertoire in HSP (
) and HSN (
) individuals.
| | | HSPs
(%) | HSNs
(%) | OR | 95% CI | | -adj |
| | Activating genes | | | | | | | | 2DS1 | 30 (63.8) | 32 (68.0) | 0.82 | 0.35–1.94 | 0.828 | 0.035 | | 2DS2 | 40 (85.1) | 34 (72.3) | 0.89 | 0.38–2.11 | 0.207 | 0.014 | | 2DS3 | 30 (63.8) | 24 (51.0) | 1.69 | 0.74–3.86 | 0.297 | 0.021 | | 2DS4-Nor | 40 (85.1) | 42 (89.0) | 0.68 | 0.16–2.65 | 0.759 | 0.028 | | 2DS4-Del | 38 (80.8) | 38 (80.8) | 1.00 | 0.36–2.89 | 1.000 | 0.042 | | 2DS5 | 35 (74.4) | 36 (76.5) | 0.89 | 0.34–2.28 | 1.000 | 0.050 | | 3DS1 | 34 (72.3) | 43 (91.4) | 0.24 | 0.07–0.81 | 0.006* | | | Inhibitory genes | | | | | | | | 2DL1 | 38 (80.8) | 40 (85.1) | 0.73 | 0.25–2.18 | 0.411 | 0.011 | | 2DL2 | 37 (78.2) | 38 (80.1) | 0.87 | 0.31–2.40 | 1.000 | 0.044 | | 2DL3 | 34 (72.3) | 36 (76.5) | 0.79 | 0.31–2.02 | 0.813 | 0.038 | | 2DL4 | 40 (85.1) | 42 (89.3) | 0.68 | 0.19–2.31 | 0.759 | 0.027 | | 2DL5 A | 28 (59.5) | 32 (68.0) | 0.69 | 0.29–1.60 | 0.520 | 0.016 | | 2DL5 B | 35 (74.6) | 24 (51.0) | 2.79 | 1.17–6.67 | 0.032* | 0.005 | | 3DL1 | 37 (78.7) | 39 (82.9) | 0.75 | 0.27–2.13 | 0.793 | 0.033 | | 3DL2 | 45 (95.7) | 45 (95.7) | 1.00 | 0.13–7.41 | 1.000 | 0.050 | | 3DL3 | 44 (93.6) | 46 (97.8) | 0.31 | 0.31–3.18 | 0.617 | 0.022 | | Pseudogenes | | | | | | | | 2DP1 | 44 (93.6) | 43 (91.4) | 1.36 | 0.28–6.46 | 1.000 | 0.050 | | 3DP1*003 | 39 (82.9) | 41 (87.2) | 0.71 | 0.22–2.24 | 0.773 | 0.033 | | 3DP1*001-004 | 13 (27.6) | 17 (36.1) | 0.67 | 0.28–1.61 | 0.507 | 0.016 |
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HSPs: HIV seropositive spouses; HSNs: HIV seronegative spouses; OR: odds ratio; CI: confidence interval; -values <0.05 are considered statistically significant; -adj: bonferroni correction values; Nor: normal; Del: deleted. Considered significant after boneferroni correction.
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