Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta
Histological characterization of healthy and creta placentas. Representative histological sections revealing cytokeratin-reactive cells in the placental bed of (a–d) term healthy placenta (36 gw) and (e–j) creta placentas (accreta: (e), (g), and (i); percreta: (f), (h), and (j)). Note cytokeratin-reactive cells (brownish color) disposed in healthy placentas as a group of large, polygonal cells that apparently do not maintain contact with other cells (a–d). In (b) note a typical multinucleate trophoblast cell. (e–j) In creta placenta samples, cytokeratin-positive cells are organized as group of compact cells (e–g) or as isolated star-shaped cells (i-j). Arrows indicate multinucleate trophoblast cells (h). Immunoperoxidase, Mayer’s hematoxylin counterstaining.