Research Article

The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Table 3

Clinical and demographic characteristics in the ACS and DM2 groups related to Del/Ins polymorphism of HLA-G by genetic models.

Phenotype ACS ( )Codominant Dominant Recessive
Del/Del (27)Del/Ins (40)Ins/Ins (19)OR (CI)Del/Del (27)Del/Ins + Ins/Ins (59)OR (CI)Del/Del +Del /Ins (67)Ins/Ins (19)OR (CI)

F/M 23/638/1911/296/13
UA 123720.94 (0.15–6.26)1.00391.44 (0.36–5.81)0.751020.67 (0.10–3.36)0.63
STEMI 692332140.16 (0.05–0.59)0.7023460.62 (0.18–2.10)0.4355140.61 (0.18–2.02)0.41
NSTEMI 51134.88 (0.47–50.98)0.29141.89 (0.20–17.77)1.00236.09 (0.94–39.58)0.06
DM2 36121950.45 (0.13–1.59)0.2312240.86 (0.34–2.15)0.743150.40 (0.134–1.28)0.12
HBP 451024112.34 (0.70–7.76)0.2310352.48 (0.97–6.33)0.0534111.34 (0.48–3.73)0.58
DYS 2161230.66 (0.14–3.03)0.726151.19 (0.41–3.51)1.001830.51 (0.13–1.96)0.32

Phenotype DM2 ( )Codominant Dominant Recessive
Del/Del (16)Del/Ins (45)Ins/Ins (9)OR (CI)Del/Del (16)Del/Ins + Ins/Ins (54)OR (CI)Del/Del + Del/Ins (61)Ins/Ins (9)OR (CI)

F/M 43/2712/428/177/2
Overweight 3562361.93 (0.615–6.07)0.236291.93 (0.62–6.07)0.402962.21 (0.51–9.63)0.28
HBP 346*2081.65 (0.15–1.60) 0.026281.80 (0.57–5.64)0.312683.03 (0.01–5.80) 0.04
Renal complications 71600.54 (0.02–14.76)1.00161.88 (0.21–16.84)1.00700.38 (0.02–7.27)0.28
Retinal complications 1318412 (1.07–134.11)0.051124.29 (0.51–35.83)0.27944.62 (1.04–20.57)0.05
Dental complications 2121458.75 (1.2–63.428)0.062193.8 (0.78–18.51)0.081653.51 (0.84–14.73)0.07
Cataracts 83410.54 (0.05–6.14)1.00350.44 (0.09–2.10)0.29711.02 (0.11–9.39)0.98

F: female, M: male, UA: unstable angina (use as reference with ACS types), STEMI: ST elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, DM2: type 2 diabetes mellitus, HBP: high blood pressure, DYS: dyslipidemia, COPD: chronic obstructive pulmonary disease, NS: not significant. versus : Del/Del versus Ins/Ins. : OR corrected, Significant comparisons are highlighted in bold font.