Research Article
The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus
Table 3
Clinical and demographic characteristics in the ACS and DM2 groups related to Del/Ins polymorphism of HLA-G by genetic models.
|
Phenotype |
ACS () | Codominant | | Dominant | | Recessive | | Del/Del (27) | Del/Ins (40) | Ins/Ins (19) | OR (CI) | Del/Del (27) | Del/Ins + Ins/Ins (59) | OR (CI) | Del/Del +Del /Ins (67) | Ins/Ins (19) | OR (CI) |
| F/M |
23/63 | 8/19 | 11/29 | 6/13 | — | — | — | — | — | — | — | — | — | — | UA |
12 | 3 | 7 | 2 | 0.94 (0.15–6.26) | 1.00 | 3 | 9 | 1.44 (0.36–5.81) | 0.75 | 10 | 2 | 0.67 (0.10–3.36) | 0.63 | STEMI |
69 | 23 | 32 | 14 | 0.16 (0.05–0.59) | 0.70 | 23 | 46 | 0.62 (0.18–2.10) | 0.43 | 55 | 14 | 0.61 (0.18–2.02) | 0.41 | NSTEMI |
5 | 1 | 1 | 3 | 4.88 (0.47–50.98) | 0.29 | 1 | 4 | 1.89 (0.20–17.77) | 1.00 | 2 | 3 | 6.09 (0.94–39.58) | 0.06 | DM2 |
36 | 12 | 19 | 5 | 0.45 (0.13–1.59) | 0.23 | 12 | 24 | 0.86 (0.34–2.15) | 0.74 | 31 | 5 | 0.40 (0.134–1.28) | 0.12 | HBP |
45 | 10 | 24 | 11 | 2.34 (0.70–7.76) | 0.23 | 10 | 35 | 2.48 (0.97–6.33) | 0.05 | 34 | 11 | 1.34 (0.48–3.73) | 0.58 | DYS |
21 | 6 | 12 | 3 | 0.66 (0.14–3.03) | 0.72 | 6 | 15 | 1.19 (0.41–3.51) | 1.00 | 18 | 3 | 0.51 (0.13–1.96) | 0.32 |
|
Phenotype |
DM2 () | Codominant | | Dominant | | Recessive | | Del/Del (16) | Del/Ins (45) | Ins/Ins (9) | OR (CI) | Del/Del (16) | Del/Ins + Ins/Ins (54) | OR (CI) | Del/Del + Del/Ins (61) | Ins/Ins (9) | OR (CI) |
| F/M |
43/27 | 12/4 | 28/17 | 7/2 | — | — | — | — | — | — | — | — | — | — | Overweight |
35 | 6 | 23 | 6 | 1.93 (0.615–6.07) | 0.23 | 6 | 29 | 1.93 (0.62–6.07) | 0.40 | 29 | 6 | 2.21 (0.51–9.63) | 0.28 | HBP |
34 | 6* | 20 | 8† | 1.65 (0.15–1.60) ‡ | 0.02 | 6 | 28 | 1.80 (0.57–5.64) | 0.31 | 26 | 8 | 3.03 (0.01–5.80) ‡ | 0.04 | Renal complications |
7 | 1 | 6 | 0 | 0.54 (0.02–14.76) | 1.00 | 1 | 6 | 1.88 (0.21–16.84) | 1.00 | 7 | 0 | 0.38 (0.02–7.27) | 0.28 | Retinal complications |
13 | 1 | 8 | 4 | 12 (1.07–134.11) | 0.05 | 1 | 12 | 4.29 (0.51–35.83) | 0.27 | 9 | 4 | 4.62 (1.04–20.57) | 0.05 | Dental complications |
21 | 2 | 14 | 5 | 8.75 (1.2–63.428) | 0.06 | 2 | 19 | 3.8 (0.78–18.51) | 0.08 | 16 | 5 | 3.51 (0.84–14.73) | 0.07 | Cataracts |
8 | 3 | 4 | 1 | 0.54 (0.05–6.14) | 1.00 | 3 | 5 | 0.44 (0.09–2.10) | 0.29 | 7 | 1 | 1.02 (0.11–9.39) | 0.98 |
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F: female, M: male, UA: unstable angina (use as reference with ACS types), STEMI: ST elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, DM2: type 2 diabetes mellitus, HBP: high blood pressure, DYS: dyslipidemia, COPD: chronic obstructive pulmonary disease, NS: not significant. versus: Del/Del versus Ins/Ins. : OR corrected, Significant comparisons are highlighted in bold font.
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