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BioMed Research International
Volume 2014, Article ID 901428, 9 pages
http://dx.doi.org/10.1155/2014/901428
Research Article

Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis

1Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
2Taicang Center for Translational Bioinformatics Center for Systems Biology, Taicang 215400, China
3Department of Pathology, Soochow University School of Medicine, Suzhou 215123, China
4Center for Systems Biology, Soochow University, No. 1 Shizi Street, Suzhou 215006, China
5School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China

Received 17 January 2014; Accepted 29 March 2014; Published 28 May 2014

Academic Editor: Degui Zhi

Copyright © 2014 Wenying Yan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancers (GC) have the high morbidity and mortality rates worldwide and there is a need to identify sufficiently sensitive biomarkers for GC. MicroRNAs (miRNAs) could be promising potential biomarkers for GC diagnosis. We employed a systematic and integrative bioinformatics framework to identify GC-related microRNAs from the public microRNA and mRNA expression dataset generated by RNA-seq technology. The performance of the 17 candidate miRNAs was evaluated by hierarchal clustering, ROC analysis, and literature mining. Fourteen have been found to be associated with GC and three microRNAs (miR-211, let-7b, and miR-708) were for the first time reported to associate with GC and may be used for diagnostic biomarkers for GC.