Research Article

Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages

Figure 3

Solid phase synthesis of the derivative VI. Reagents and conditions: (i) 20% Piperidine in DMF; (ii) 0.2 M HATU in DMF, 0.2 M DIPEA, 0.3 M Lutidine in DMF; (iii) 2% DCA in DCM; (iv) 0.1 M CPR in ACN, 0.3 M BTT in ACN; (v) I2/H2O/pyridine.
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